Clinical trials in Leiden – page 91

1 938 clinical trials in Leiden, The Netherlands across 4 research sites. Every trial is listed in the EU Clinical Trials Register and updated daily.

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1 938

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1 938 trials in Leiden

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Systemic lupus erythematosus

Not recruiting

Evaluation of safety and efficacy of 19CP02 combined with cyclophosphamide and fludarabine phosphate in adults with treatment‑refractory active systemic lupus erythematosus

Registered drugNo placebo

Evaluation of safety and efficacy of 19CP02 combined with cyclophosphamide and fludarabine phosphate in adults with treatment‑refractory active systemic lupus erythematosus

Registered drugNo placebo

The Netherlands

Participants:18–64 years
Substances:Cyclophosphamide
Sponsor:Galapagos

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Study to evaluate the effects of brexanolone and lorazepam on the nervous system in healthy male participants using magnetic brain stimulation

Not recruiting

Registered drug

Study to evaluate the effects of brexanolone and lorazepam on the nervous system in healthy male participants using magnetic brain stimulation

Registered drug

The Netherlands

Participants:18–64 years · Healthy volunteers
Substances:Brexanolone
Sponsor:Sage Therapeutics Inc.

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Dermatitis atopic

Not recruiting

Safety and Tolerability of Topical Iodine (DLQ03) in Patients with Mild to Moderate Atopic Dermatitis Colonized with Staphylococcus aureus

Registered drug

Safety and Tolerability of Topical Iodine (DLQ03) in Patients with Mild to Moderate Atopic Dermatitis Colonized with Staphylococcus aureus

Registered drug

The Netherlands

Participants:18–64 years · 65+ years
Substances:Iodine
Sponsor:Dermaliq Therapeutics Inc.

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Systemic lupus erythematosus

Not recruiting

Efficacy and Safety Evaluation of Litifilimab in Adults with Active Systemic Lupus Erythematosus on Standard Nonbiologic Lupus Care: A Phase 3 Randomized Controlled Trial

Investigational

Efficacy and Safety Evaluation of Litifilimab in Adults with Active Systemic Lupus Erythematosus on Standard Nonbiologic Lupus Care: A Phase 3 Randomized Controlled Trial

Investigational

The Netherlands

Participants:18–64 years · 65+ years
Substances:Litifilimab
Sponsor:Biogen Idec Research Limited

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Osteosarcoma

Not recruiting

Efficacy and Safety of Maintenance Cabozantinib Plus Best Supportive Care in Pediatric and AYA Patients with Unresectable Residual Osteosarcoma

Registered drugNo placebo

Efficacy and Safety of Maintenance Cabozantinib Plus Best Supportive Care in Pediatric and AYA Patients with Unresectable Residual Osteosarcoma

Registered drugNo placebo

The Netherlands

Participants:0–17 years · 18–64 years
Substances:Cabozantinib
Sponsor:Ipsen Innovation

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Hormone-dependent prostate cancer+1

Not recruiting

A Study of Mevrometostat and Enzalutamide for Men with Metastatic Castration-Sensitive Prostate Cancer Who Have Not Received Hormonal Therapy or Chemotherapy

Registered drug

A Study of Mevrometostat and Enzalutamide for Men with Metastatic Castration-Sensitive Prostate Cancer Who Have Not Received Hormonal Therapy or Chemotherapy

Registered drug

The Netherlands

Participants:18–64 years · 65+ years
Substances:Enzalutamide
Sponsor:Pfizer Inc.

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Dementia Alzheimer's type

Not recruiting

A study testing MK-1167 added to current treatment in patients with mild to moderate Alzheimer's disease dementia

Investigational

A study testing MK-1167 added to current treatment in patients with mild to moderate Alzheimer's disease dementia

Investigational

The Netherlands

Participants:18–64 years · 65+ years
Substances:MK-1167
Sponsor:Merck Sharp & Dohme LLC

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Gastric cancer+6

Not recruiting

A Study of CLDN6 CAR-T Cell Therapy With or Without CLDN6 RNA-LPX Vaccine in Patients With CLDN6-Positive Advanced Solid Tumors That Returned or Did Not Respond to Treatment

InvestigationalNo placebo

A Study of CLDN6 CAR-T Cell Therapy With or Without CLDN6 RNA-LPX Vaccine in Patients With CLDN6-Positive Advanced Solid Tumors That Returned or Did Not Respond to Treatment

InvestigationalNo placebo

The Netherlands

Participants:18–64 years · 65+ years
Sponsor:BioNTech Cell & Gene Therapies GmbH

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Prostate cancer

Not recruiting

Study of xaluritamig compared to cabazitaxel or androgen receptor therapy for patients with metastatic castration-resistant prostate cancer

Registered drugNo placebo

Study of xaluritamig compared to cabazitaxel or androgen receptor therapy for patients with metastatic castration-resistant prostate cancer

Registered drugNo placebo

The Netherlands

Participants:18–64 years · 65+ years
Substances:Abiraterone Acetate
Sponsor:Amgen Inc.

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Colorectal cancer metastatic

Not recruiting

A Study Comparing Telisotuzumab Adizutecan to Trifluridine, Tipiracil, and Bevacizumab in Adults with Refractory Metastatic Colorectal Cancer

Registered drugNo placebo

A Study Comparing Telisotuzumab Adizutecan to Trifluridine, Tipiracil, and Bevacizumab in Adults with Refractory Metastatic Colorectal Cancer

Registered drugNo placebo

The Netherlands

Participants:18–64 years · 65+ years
Substances:Bevacizumab
Sponsor:AbbVie Deutschland GmbH & Co. KG

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Alcoholic liver disease

Not recruiting

A study testing NNC0194-0499, cagrilintide, and semaglutide alone or combined to treat liver damage in people with alcohol-related liver disease

Investigational

A study testing NNC0194-0499, cagrilintide, and semaglutide alone or combined to treat liver damage in people with alcohol-related liver disease

Investigational

The Netherlands

Participants:18–64 years · 65+ years
Substances:Cagrilintide
Sponsor:Novo Nordisk A/S

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Epilepsy

Not recruiting

A study of TRV045 to test its effects on brain cell electrical activity in healthy adult men for epilepsy treatment development

Investigational

A study of TRV045 to test its effects on brain cell electrical activity in healthy adult men for epilepsy treatment development

Investigational

The Netherlands

Participants:18–64 years · Healthy volunteers
Substances:TRV045
Sponsor:Trevena Inc.

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Clinical research in Leiden

What the registry says about research in the country

01 Infectious Diseases Research

Innovative studies focusing on viral infections including trials evaluating vaccines against yellow fever, influenza, and mpox. Research includes assessment of antibody responses and vaccine effectiveness in different populations.

Influenza vaccine efficacy in elderly
Yellow fever prophylaxis
Mpox booster vaccination

Particular emphasis on preventive strategies and immune response evaluation.

02 Neurological Studies

Comprehensive research targeting neurological conditions, including investigations into Parkinson's disease treatments and neural response patterns. Studies examine innovative therapeutic approaches.

Parkinson's Disease treatments
CNS response analysis
Cerebral Amyloid Angiopathy

Focus on developing targeted therapies and understanding brain mechanisms.

03 Cancer and Chronic Conditions

Advanced research in oncology and chronic diseases, including studies on gastric cancer imaging and T-cell lymphoma treatments. Investigations into kidney disease management.

Advanced solid tumors
Gastric cancer diagnosis
Chronic kidney disease

Emphasis on innovative diagnostic techniques and treatment approaches.

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