The study focuses on women who have been diagnosed with Major depressive disorder, a condition that causes persistent sadness, loss of interest, and difficulty concentrating. All participants will receive the standard antidepressant medication sertraline taken by mouth. The trial is testing whether adding a second drug, prucalopride, which works on a brain chemical pathway, can improve mood and memory compared with a dummy pill, placebo. The purpose of the study is to determine if this additional medication can enhance the response to antidepressant treatment and improve thinking abilities.
Participants will start the study by taking sertraline daily. They will be randomly assigned to also receive either prucalopride or a placebo for eight weeks, while continuing sertraline. Throughout the eight‑week period, researchers will check mood using simple questionnaires and will test memory with short spoken‑word tasks at the beginning and at the end of the study. After the eight weeks, the collected information will be compared to see whether the group receiving prucalopride shows lower levels of depressive feelings and better verbal memory.
Denmark 
