The study involves women who have difficulty becoming pregnant because of infertility and low ovarian reserve. In an effort to improve the outcome of IVF cycles that use fresh embryo transfer, the trial will compare three ways of triggering ovulation, including the usual hormone called hCG, a combination of hCG plus a newer medication called follitropin delta, and an alternative medicine known as ganirelix acetate. The purpose of the study is to find out whether adding follitropin delta to the standard trigger increases the number of mature eggs, referred to as MII eggs, that can be collected for fertilization.
Participants will go through a normal IVF process, receiving hormone injections to grow multiple follicles, and then be randomly assigned to one of the three trigger groups. After the trigger injection, eggs are retrieved, fertilized in the laboratory, and the resulting embryos are placed back into the uterus in the same cycle. The study follows each woman through egg collection, embryo transfer, and early pregnancy testing, recording how many mature eggs are obtained, the rate of pregnancy, and some laboratory measurements of gene activity in the eggs.
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