The study looks at adults with relapsed or refractory large B-cell lymphoma, a type of blood cancer that has returned after treatment or did not respond to initial therapy. The two treatments being compared are KITE-753 and axicabtagene ciloleucel, both given as an intravenous infusion. These are forms of cell therapy designed to help the immune system attack cancer cells.
The purpose of the study is to determine which of the two therapies works better at controlling the disease. Participants will be randomly assigned to receive one of the two treatments, followed by regular check‑ups that may include scans such as positron emission tomography-computed tomography to look for any remaining cancer and assessments of overall health and quality of life. The study continues for several months after treatment to monitor how well the disease is controlled and to record any side effects.



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