This study involves atopic dermatitis, which is a skin condition that causes red, itchy, and inflamed patches on the skin. The study will use two different moisturizing creams. The first cream contains urea and propylene glycol at specific strengths. The second cream is called Oviderm, which contains propylene glycol. These creams will be compared to using no treatment at all. The purpose of the study is to see if these moisturizing creams can help prevent the return of eczema symptoms better than not using any treatment.
The study is designed as a split-body study, which means that different treatments will be applied to different areas of the body on the same person. Before starting the maintenance treatment with the creams, patients will first receive treatment with a corticosteroid cream, which is a medication that reduces inflammation, for about four weeks to clear the skin lesions. Corticosteroids are commonly used to treat skin inflammation and help calm down active eczema flare-ups. Once the skin has cleared, the maintenance phase begins, where one moisturizing cream will be applied to one study area on the body, another cream or no treatment will be applied to another area, and this will continue for up to 90 days or until the eczema comes back.
During the study, the time it takes for the eczema to return on each treated area will be measured, which is the main focus of the research. Other aspects that will be looked at include how itching changes over time in the different areas and whether any unwanted effects occur during the treatment period. Patients will report when they notice their eczema returning and how much itching they experience using a rating scale.
Norway 
Sweden 
