Infectious Diseases

The department focuses on viral and bacterial infections, aiming to improve treatment options and patient outcomes across a range of serious illnesses.

  • HSV-2 meningitis – evaluating antiviral therapy effectiveness.
  • COVID-19 in high‑risk non‑hospitalized adults – testing oral antivirals.
  • Staphylococcus aureus bacteremia – comparing short versus extended antibiotic courses.
  • Sepsis and septic shock – assessing empirical antibiotic strategies in intensive care.
  • Chronic rhinosinusitis without nasal polyps – investigating novel anti‑inflammatory agents.

These studies seek to refine diagnostics, reduce mortality, and enhance quality of care for patients facing infectious threats.

Oncology

Research in the oncology field targets breast cancer subtypes, exploring new targeted therapies and combination regimens to extend survival.

  • HR+/HER2‑ advanced/metastatic breast cancer – testing kinase inhibitors with endocrine therapy.
  • HER2‑positive metastatic breast cancer – evaluating antibody‑drug conjugates, with and without brain metastases.
  • Node‑positive estrogen receptor‑positive early breast cancer – assessing novel endocrine agents for recurrence prevention.

The goal is to demonstrate superior disease control and improve long‑term outcomes for women and men affected by breast cancer.

Gastroenterology

The site conducts trials in inflammatory bowel disease, focusing on both ulcerative colitis and Crohn’s disease to find safer, more effective treatments.

  • Moderately to severely active Crohn’s disease – oral selective inhibitors evaluated for remission.
  • Moderately to severely active ulcerative colitis – endoscopic response and clinical remission as primary endpoints.

Long‑term safety and tolerability are also examined to support sustained disease management.

Cardiology

Cardiovascular research addresses chronic heart failure, seeking interventions that lower mortality and reduce hospital admissions.

  • Chronic heart failure with reduced ejection fraction – testing hydralazine‑ISDN and metformin as adjunct therapies.

By targeting neuro‑hormonal pathways and metabolic modulation, these trials aim to improve functional capacity and survival.

Orthopedics

Orthopedic investigations evaluate pain management and functional recovery for common fracture injuries.

  • Distal radius fracture – ultrasound‑guided brachial plexus nerve block compared with standard care.

The study measures analgesic effectiveness and facilitates early mobilization after closed reduction.

Critical Care

The intensive care platform explores best practices for patients admitted with life‑threatening conditions, aiming to standardize care across clinicians.

  • Acute critical illness requiring ICU admission – platform trial assessing varied interventions.
  • Sepsis and septic shock – evaluating mortality and organ support outcomes.

Findings are intended to inform evidence‑based protocols and improve survival rates in the ICU setting.