This study aims to evaluate how normal aging and Parkinson’s disease affect the availability of specific receptors in the brain. The research focuses on the noradrenergic system, which is a group of brain cells and chemicals that help regulate various body functions. Specifically, the investigation looks at the alpha2C-adrenergic receptors, which are special proteins in the brain that play a role in how certain messages are sent between nerve cells.

To conduct this research, a substance called [11C]ORM-13070 will be used. This substance is a radiotracer, which is a special compound used to create images of how the body is functioning at a cellular level. This tracer is administered through an injection. The study also utilizes PET and MRI imaging to observe the brain. PET is a method used to visualize biological processes, while MRI is a technique that uses magnetic fields to create detailed pictures of the organs and tissues within the body.

During the study, the brain is examined to look at the locus coeruleus, an area of the brain involved in the noradrenergic system. Researchers will also observe how these brain processes relate to various functions such as memory, language, sleep, and mood. The procedure involves monitoring how the radiotracer interacts with the brain receptors to better understand the changes that occur during aging and in the presence of neurological conditions.