ORTHOALLO-BM-MSC (human bone marrow mesenchymal stem cells) is a cell therapy treatment made from donor bone marrow cells. These specialized cells are used to help heal bones that have not properly healed after a fracture. The cells work by promoting new bone formation and supporting the natural healing process.

Biomaterial is a special material designed to be placed at the site of the bone fracture. It acts as a scaffold or support structure that works together with the stem cells to help the bone heal properly. The biomaterial provides a framework for new bone growth and helps keep the stem cells in place where they are needed.

The combination of these two treatments (ORTHOALLO-BM-MSC and Biomaterial) is used together as a single therapy to treat bones that have either delayed healing or failed to heal properly after a fracture.

Delayed Bone Fracture Union – A condition where a broken bone takes longer than expected to heal, typically extending beyond the normal 3-6 month healing period. The healing process is slower than usual but still shows signs of progression, with the bone fragments gradually forming connections.

Non-union Long Bone Fracture – A serious condition where a broken bone fails to heal and unite properly, even after six months from the initial injury. The fracture shows no signs of healing progress over three consecutive months, leaving a persistent break in the bone. This condition most commonly affects major bones in the arms and legs. The broken bone ends remain separated, and natural healing processes have stopped, resulting in continued instability at the fracture site.