This study focuses on patients with borderline resectable pancreatic adenocarcinoma, which is a type of pancreatic cancer that may be surgically removed after initial treatment. The study aims to evaluate the effectiveness of different chemotherapy combinations based on specific genetic markers in the tumor tissue before surgery.
The study uses several chemotherapy medications including gemcitabine, paclitaxel, fluorouracil, irinotecan, oxaliplatin, and folinic acid. Some patients will receive a combination of gemcitabine and paclitaxel, while others will receive a combination of the other medications. The choice of treatment will be based on specific genetic patterns found in the tumor tissue.
The treatment involves receiving chemotherapy for 4 months before surgery. After surgery, patients will continue to be monitored to evaluate how well the treatment worked. Throughout the study, doctors will track various measures of treatment success, including whether the cancer returns and how long patients live without the disease getting worse.



France