Prucalopride is a medication that works by activating 5-HT4 receptors in the body. It is typically used to treat severe constipation, but in this study, it is being investigated for its potential to enhance the effectiveness of antidepressant treatment.

Escitalopram is an antidepressant medication that belongs to a group called selective serotonin reuptake inhibitors (SSRIs). It works by increasing the levels of serotonin in the brain, which helps improve mood, reduce anxiety, and relieve symptoms of depression.

The study aims to see if combining these two medications can help people with depression respond better and faster to antidepressant treatment than using escitalopram alone.

Major Depressive Disorder – A mood disorder characterized by persistent feelings of sadness, loss of interest in activities, and decreased energy lasting for at least two weeks. The condition affects how a person thinks, feels, and behaves, often leading to emotional and physical problems. People with depression may experience changes in sleep patterns, appetite, concentration, and daily activities. The disorder can develop gradually and may be triggered by life events, though sometimes there is no obvious cause. Depression affects the brain’s ability to regulate mood through neurotransmitters, particularly serotonin. The condition can vary in severity and duration, with symptoms fluctuating over time.