REGN7508 is an experimental antibody medication given by intravenous (IV) injection. It works by targeting a blood clotting factor called Factor XI to help prevent blood clots from forming after knee replacement surgery.

Apixaban is a blood-thinning medication taken as a pill. It helps prevent blood clots by blocking one of the proteins involved in blood clotting. It is commonly used to reduce the risk of blood clots after surgery.

Enoxaparin is a blood-thinning medication given by injection under the skin. It belongs to a group of medications called low molecular weight heparins and works by preventing blood clots from forming or getting larger. It is frequently used to prevent blood clots in patients who have had surgery.

Venous Thromboembolism (VTE) – A condition where blood clots form in the veins, most commonly in the legs or pelvis. The clots can break off and travel through the bloodstream, potentially blocking blood vessels in other parts of the body. VTE encompasses both deep vein thrombosis and pulmonary embolism.

Deep Vein Thrombosis (DVT) – A blood clot that develops in a deep vein, usually in the leg or pelvis. The affected area may become swollen, painful, and warm to the touch. DVT can cause long-term problems with blood flow in the affected limb.

Pulmonary Embolism (PE) – A condition that occurs when a blood clot travels to the lungs and blocks a pulmonary artery or one of its branches. It typically develops as a complication of deep vein thrombosis. The condition can cause difficulty breathing, chest pain, and rapid heartbeat.

Thromboembolic Disease – A broad term for conditions characterized by the formation of blood clots that can travel through blood vessels. It includes both arterial and venous blood clot formation. The condition can affect various parts of the body and may develop gradually or suddenly.