This study focuses on patients with Hand Osteoarthritis, a condition that causes pain and stiffness in the hand joints. The research examines the effectiveness of methylprednisolone acetate, a medication that helps reduce inflammation and pain, when given as an injection into the muscle. The study compares two different doses of the medication (40mg and 120mg) against a placebo to determine how well it works for reducing hand pain.

The medication will be given as a single intramuscular injection, which means it is injected directly into a muscle. Some patients will receive the actual medication (Depo-Medrol), while others will receive sodium chloride solution as a placebo. The study will track how participants’ hand pain changes over time, particularly during the first four weeks after the injection.

Throughout the study, which lasts 48 weeks, researchers will monitor various aspects of the participants’ condition, including pain levels, hand function, and quality of life. They will also look at changes in joint structure and inflammation to better understand how the treatment works. This research aims to find out if this type of injection could be an effective treatment option for people with hand osteoarthritis who haven’t found sufficient relief from other pain medications.