This study focuses on treating patients with cardiac arrest, specifically when the heart stops beating in a pattern that cannot be treated with an electric shock. The research examines whether combining two medications – isoprenaline and epinephrine – works better than using epinephrine alone when treating people whose hearts have stopped beating outside of a hospital.
The treatment involves giving medications through an intravenous bolus (a quick injection into a vein). Some patients will receive both isoprenaline and epinephrine, while others will receive epinephrine and a placebo. The study aims to determine if the combination of these medications can improve the chances of restarting the heart and maintaining its rhythm.
During the study, medical professionals will administer these treatments as part of standard emergency care procedures when they attend to people experiencing cardiac arrest outside of the hospital. The maximum dose of isoprenaline that may be given is 1600 micrograms per day. This research focuses specifically on cases where the heart has stopped in a way that cannot be treated with a defibrillator (the device that delivers electric shocks to the heart).
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