This study focuses on pulmonary tuberculosis and bacterial pneumonia. The research aims to evaluate new ways to diagnose and monitor tuberculosis using blood sample tests. The study will examine two specific measurements: the Molecular Bacterial Load Assay and RNA Synthesis Ratio, which are tests that may help identify and track the progress of tuberculosis infection.
Participants diagnosed with tuberculosis will receive standard treatment consisting of two medication combinations. The first combination includes isoniazid, pyrazinamide, rifampicin, and ethambutol hydrochloride taken as tablets for two months. This is followed by a second combination of isoniazid and rifampicin tablets for four months. Throughout the treatment period, researchers will collect blood samples to measure various indicators of disease activity.
The study will also use advanced imaging techniques including PET/MRI scans to monitor how the disease responds to treatment. These scans create detailed pictures of the lungs and can show how the infection changes over time. Blood and sputum (mucus coughed up from the lungs) samples will be collected to measure various substances that might indicate how well the treatment is working.
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