Fosfomycin is an antibiotic used to treat infections caused by bacteria. In this trial, it is administered directly into the abdominal cavity to help fight the infection in patients with peritonitis, which is an inflammation of the inner lining of the abdomen. By delivering the medication directly to the site of infection, it aims to effectively reduce the bacterial load and improve the patient’s condition.

Metronidazole is another antibiotic that is effective against certain types of bacteria and parasites. In this study, it is also given directly into the abdominal area to target and eliminate the bacteria causing the infection. This approach is intended to enhance the treatment of peritonitis by ensuring that the medication reaches the affected area quickly and efficiently.

Recombinant Human Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF) is a substance that helps stimulate the body’s immune system. It encourages the production of white blood cells, which are crucial for fighting infections. In this trial, GM-CSF is used to boost the patient’s immune response, helping their body to better combat the infection associated with peritonitis.

Peritonitis – Peritonitis is an inflammation of the peritoneum, the thin layer of tissue that lines the inside of the abdomen and covers most of the abdominal organs. It typically occurs due to a bacterial or fungal infection, often resulting from a rupture in the abdominal wall or an infection spreading from another part of the body. The condition can cause severe abdominal pain, tenderness, and swelling, often accompanied by fever and nausea. As the inflammation progresses, it can lead to the accumulation of fluid in the abdominal cavity and a decrease in bowel movements. If not addressed, the inflammation can spread, affecting other organs and leading to more severe complications. The progression of peritonitis can vary depending on the underlying cause and the individual’s overall health.