This clinical trial is focused on studying the effects of a medication called donepezil hydrochloride on certain brain functions in older adults. The study involves healthy volunteers aged 50 and above. Donepezil hydrochloride is a medication commonly used to increase levels of a chemical in the brain called acetylcholine, which is important for memory and learning. The trial will compare the effects of a single 5 mg dose of donepezil hydrochloride with a placebo, which looks like the medication but does not contain the active ingredient.
The purpose of the study is to understand how donepezil hydrochloride affects cognitive and motor functions, which are related to thinking and movement, in older adults. Participants will be asked to perform tasks that require both thinking and physical movement, known as dual-task activities. The study will measure how well participants perform these tasks after taking either the medication or the placebo. Additionally, the study will use a technique called MRI (Magnetic Resonance Imaging) to observe brain activity during these tasks.
The trial will take place over a short period, with participants attending two visits. During these visits, they will complete various tests to assess their cognitive and motor skills. The results will help researchers understand the potential benefits of donepezil hydrochloride in improving brain function in older adults. This study is important for exploring new ways to support healthy aging and cognitive health.
Germany 
