This clinical trial focuses on treating difficult-to-treat hypertension, a condition where blood pressure remains high despite current treatments. The study evaluates several medications including Elestar HCT (containing olmesartan medoxomil, amlodipine, and hydrochlorothiazide) and Triplixam (containing indapamide, amlodipine besilate, and perindopril arginine). Additional medications being studied include Spironol, Toramide, and Espiro.
The purpose of the study is to find the most effective treatment approach for patients whose high blood pressure is not well controlled with their current medications. The study is divided into three phases to evaluate different treatment strategies and compare the effectiveness of various medication combinations.
During the trial, participants will receive different combinations of blood pressure medications as tablets taken by mouth. The treatment period lasts up to 30 weeks, during which doctors will monitor blood pressure using various measurement methods to determine how well the medications are working. The medications being tested include different types of drugs that work in various ways to lower blood pressure, such as water pills (diuretics), calcium channel blockers, and drugs that affect blood vessel function.
Poland 
