Clindamycin is an antibiotic used to treat various types of infections. In this trial, researchers are studying how the body absorbs and processes clindamycin, especially in people with different body weights. They want to understand how well clindamycin works in treating infections.

Rifampicin is another antibiotic that is often used to treat infections, including tuberculosis. In this trial, researchers are examining how taking rifampicin at the same time as clindamycin affects the way clindamycin works in the body. They are interested in seeing if rifampicin changes how clindamycin is absorbed and processed.

Fracture-related infections – These infections occur when bacteria invade the site of a bone fracture, leading to inflammation and potential complications in the healing process. They can cause symptoms such as redness, swelling, and pain at the fracture site. If not managed, the infection can spread to surrounding tissues and delay bone healing. The condition often requires medical intervention to prevent further complications.

Hidradenitis suppurativa – This is a chronic skin condition characterized by painful lumps under the skin, typically in areas where skin rubs together, such as the armpits, groin, and under the breasts. These lumps can become inflamed and may rupture, leading to scarring. The condition tends to flare up and can be persistent, affecting daily activities and quality of life. It is often associated with other systemic conditions.

Prosthetic joint infections – These infections occur when bacteria infect a joint that has been replaced with an artificial implant, such as a hip or knee replacement. Symptoms may include joint pain, swelling, and warmth around the joint. The infection can compromise the function of the joint and may lead to loosening of the implant. It often requires medical attention to address the infection and preserve joint function.