This clinical trial is focused on studying the effects of vitamin D on certain body tissues in elderly individuals who are obese and have a deficiency in vitamin D. The treatment being tested is a supplement called cholecalciferol, which is another name for vitamin D3. The study will also use olive oil as a comparison. The main goal is to understand how vitamin D supplementation affects inflammation, which is the body’s response to injury or infection, in these individuals.
Participants in the study will take the vitamin D supplement or olive oil by mouth over a period of 12 months. Throughout the study, various tests will be conducted to monitor changes in the body. These tests will look at different tissues, including muscle, fat, and bone, to see how they respond to the treatment. The study will also measure levels of certain proteins and genes that are involved in inflammation and other bodily processes. Additionally, the safety of taking vitamin D will be checked by measuring blood calcium levels regularly.
The study aims to provide valuable information on how vitamin D can help manage inflammation in people who are both elderly and obese, with a specific focus on those who have low levels of vitamin D. This research could lead to better understanding and management of health issues related to vitamin D deficiency in this population. The study is expected to be completed by February 2027.



Italy