This clinical trial is focused on studying the effects of certain medications used during a procedure called pleurodesis surgery, which is performed to treat a condition known as pneumothorax. Pneumothorax occurs when air leaks into the space between the lung and chest wall, causing the lung to collapse. The study aims to evaluate the use of nonsteroidal anti-inflammatory drugs (NSAIDs) in this surgical context. The medications being studied include ketoprofen, nefopam, sodium chloride, tramadol, paracetamol, and cellulose, microcrystalline. Some of these medications are used to manage pain and inflammation, while others serve as supportive treatments during the procedure.

The purpose of the study is to determine if NSAIDs are as effective as other treatments in terms of reducing the time needed for pleural drainage, which is the removal of fluid or air from the pleural space after surgery. Participants in the study will receive one of the medications or a placebo, and their recovery will be monitored over a period of time. The study will assess various factors, including the duration of drainage, pain relief, and any complications that may arise after the surgery.

Throughout the study, participants will be closely observed to ensure their safety and to gather data on the effectiveness of the treatments. The study will also track the recurrence of pneumothorax and any other medical or surgical complications that may occur. This research is important for improving the management of pneumothorax and enhancing recovery after pleurodesis surgery.