Isoflurane is a medication used for inhaled sedation. In this study, it is administered to patients who are on mechanical ventilation in the intensive care unit. The goal is to see if using Isoflurane can reduce the occurrence of delirium compared to other sedation methods. It is delivered through a special system called ANACONDA™, which allows the medication to be inhaled directly into the lungs.

Intravenous Sedation refers to the traditional method of providing sedation through a vein. This approach is commonly used in intensive care settings for patients who require mechanical ventilation. The study compares this method to the inhaled sedation strategy to determine which is more effective in preventing delirium.

Delirium – Delirium is a sudden change in a person’s mental state, characterized by confusion, disorientation, and difficulty focusing attention. It often occurs in hospital settings, especially in intensive care units, and can fluctuate in severity throughout the day. Patients may experience hallucinations, restlessness, or agitation, and their ability to think clearly is impaired. The condition can develop quickly, often within hours or days, and is usually triggered by an underlying medical issue, such as an infection or medication side effects. Delirium is more common in older adults and those with pre-existing cognitive impairments. It is important to identify and address the underlying causes to help manage the symptoms effectively.