Cabozantinib is an oral medication used to treat various types of cancer. It works by blocking specific proteins that contribute to cancer growth and spread. In this trial, it is being studied for treating advanced neuroendocrine tumors. The medication helps reduce the formation of new blood vessels that feed tumors and can help slow down or stop cancer growth. It is taken as a tablet once daily.

Neuroendocrine Neoplasia – A condition where abnormal growths develop from cells of the neuroendocrine system, which are specialized cells that have traits of both nerve cells and hormone-producing cells. These cells can be found throughout the body, particularly in the digestive tract, pancreas, and lungs. The condition typically develops gradually, with tumors forming in various organs and potentially affecting their normal function. The disease can cause the overproduction of various hormones, leading to different symptoms depending on the location and type of cells involved.

Neuroendocrine Tumor – A specific type of growth that begins in specialized cells called neuroendocrine cells, which have characteristics similar to those of nerve cells and hormone-producing cells. These tumors can form in many parts of the body, most commonly in the gastrointestinal tract, pancreas, or lungs. The tumors may produce excess hormones, which can cause various symptoms depending on the location and type of tumor. These growths typically develop slowly over time and can vary in their behavior and effects on the body.