Collagenase Clostridium Histolyticum is an enzyme injection used to treat Dupuytren’s contracture. It works by breaking down the collagen buildup in the hand, which can help to release the fingers and improve movement. This treatment is less invasive than surgery and is used as a primary treatment option in the trial.

Percutaneous Needle Fasciotomy is a minimally invasive procedure used to treat Dupuytren’s contracture. In this procedure, a needle is used to cut the thickened tissue in the palm, allowing the fingers to straighten. It is considered a primary treatment option in the trial and is followed by surgery if necessary.

Limited Fasciectomy is a surgical procedure used to treat Dupuytren’s contracture. During this surgery, the surgeon removes the thickened tissue in the hand to improve finger movement. It is used as both a primary and secondary treatment option in the trial, especially for patients who do not respond to other treatments.

Dupuytren’s contracture – Dupuytren’s contracture is a hand condition where the fingers bend towards the palm due to thickening and shortening of the tissue beneath the skin. It typically starts with small lumps or nodules in the palm, which may gradually develop into thick cords. Over time, these cords can pull one or more fingers into a bent position, making it difficult to straighten them. The condition usually progresses slowly and can vary in severity. It most commonly affects the ring and little fingers and is more prevalent in older adults. The exact cause is unknown, but it is believed to involve genetic factors.