Ferumoxytol is an intravenous iron replacement medication used to treat iron deficiency anemia. It helps increase iron levels in the body when oral iron supplements aren’t working well enough or can’t be taken. This medication is particularly useful for people with chronic kidney disease who often develop anemia.

Iron Sucrose is an established intravenous iron treatment used to replenish iron levels in people with iron deficiency anemia. It’s commonly used in patients with chronic kidney disease who need iron supplementation. This medication serves as the comparison treatment (active control) in this study.

Iron Deficiency Anemia (IDA) – A condition where the body doesn’t have enough iron to produce adequate amounts of hemoglobin, a protein in red blood cells that carries oxygen throughout the body. The condition develops gradually as body iron stores are depleted and hemoglobin levels fall below normal. Common signs include fatigue, weakness, pale skin, and shortness of breath during physical activity.

Chronic Kidney Disease (CKD) – A gradual loss of kidney function that occurs over time. The kidneys become less efficient at filtering waste products from the blood and maintaining proper fluid balance in the body. The disease progresses through several stages, from mild damage to complete kidney failure. CKD often affects the body’s ability to produce enough red blood cells, leading to anemia.