This study focuses on patients with premature ventricular complexes (PVCs), which are extra, abnormal heartbeats that begin in the heart’s lower chambers. The study specifically looks at people who have frequent PVCs (more than 10% of total heartbeats) but don’t feel any symptoms and have normal heart function. Several medications will be tested including verapamil, nebivolol, amiodarone, propafenone, bisoprolol, diltiazem, flecainide, and sotalol.
The purpose is to determine if treating patients who have frequent PVCs but no symptoms can prevent future heart problems better than simply monitoring them without treatment. The study will last for 24 months, during which patients may receive medication or, if necessary, a procedure called ablation (which uses heat to destroy small areas of heart tissue causing irregular rhythms) if medications alone don’t reduce the PVCs enough.
Throughout the study, doctors will monitor how well the heart is pumping blood using special imaging tests like cardiac magnetic resonance imaging (cMRI) or heart ultrasound. They will also track changes in heart function, measure exercise capacity, and monitor for any side effects from the treatments.
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