This study focuses on patients with intermediate-high risk acute pulmonary embolism, a serious condition where blood clots block arteries in the lungs. The study compares two different treatment approaches: catheter-directed thrombolysis using Actilyse (also known as alteplase) versus standard blood-thinning therapy. Catheter-directed thrombolysis is a procedure where clot-dissolving medication is delivered directly to the blood clot through a thin tube.
The purpose of the study is to determine if catheter-directed thrombolysis leads to better outcomes compared to standard treatment in terms of survival, prevention of new blood clots, and overall heart and lung function. The medication Actilyse will be given through an infusion directly to the blood clot, with a maximum daily dose of 20 milligrams over the course of one day.
During the study, patients will undergo various tests to monitor their heart and lung function, including computed tomography angiography to look at blood vessels in the lungs, and heart ultrasound tests to check heart function. Patients will be followed for up to two years to assess their recovery and quality of life after treatment.



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