This clinical trial is focused on studying the treatment of an acute gout flare, a condition characterized by sudden and severe pain in the joints, often affecting the big toe. The study will use a medication called dapansutrile, which is taken in the form of a tablet. The purpose of the study is to evaluate how effective dapansutrile is in reducing joint pain compared to a placebo.

Participants in the study will be randomly assigned to receive either dapansutrile or a placebo. The study will be conducted in a double-blind manner, meaning neither the participants nor the researchers will know who is receiving the actual medication or the placebo. This helps ensure that the results are unbiased. The study will last for a short period, during which participants will take the medication and report on their pain levels at various intervals.

In addition to dapansutrile, the study will also involve the use of paracetamol, a common pain reliever, to help manage symptoms. Participants will be monitored closely to assess any changes in their condition and to ensure their safety throughout the study. The goal is to determine if dapansutrile can effectively reduce the pain associated with an acute gout flare, providing a potential new treatment option for those affected by this painful condition.