This clinical trial is focused on studying the effects of post-operative antibiotic therapy in patients who have undergone a laparoscopic appendectomy for a condition known as complicated acute appendicitis. This condition involves inflammation of the appendix that may include complications such as a perforated appendix, which means the appendix has burst, or the presence of abscesses, which are collections of pus. The study aims to evaluate the impact of not using antibiotics after surgery on the rate of infections that occur in the area of the surgery.

The trial involves several medications, including metronidazole, glucose, ceftriaxone sodium, lidocaine hydrochloride, and ofloxacin hydrochloride. These medications are administered through infusion, which means they are given directly into the bloodstream. The study also includes a group that receives a placebo, which is a substance with no active medication, to compare the effects of the antibiotics.

Participants in the study will be monitored for a period of up to three days after their surgery. The main focus is to observe the occurrence of infections at the surgical site within 30 days after the operation. Additionally, the study will look at other factors such as the quality of life before and after surgery, the number of days without antibiotics, and the balance between antibiotic use and resistance to bacteria. The goal is to understand whether antibiotics are necessary after surgery for this type of appendicitis and to ensure the best outcomes for patients.