Long-Term Safety Study of Inhaled Imatinib for Patients with Pulmonary Arterial Hypertension

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What is this study about?

This clinical trial is focused on studying the long-term safety of a treatment called AV-101 for people with Pulmonary Arterial Hypertension (PAH). PAH is a condition where the blood pressure in the arteries of the lungs is higher than normal, which can lead to heart problems. The treatment being tested, AV-101, contains an active substance known as imatinib, which is a type of medication called a tyrosine kinase inhibitor. This medication is administered through inhalation using a device called a dry powder inhaler.

The purpose of this study is to ensure that AV-101 is safe for long-term use in individuals who have already completed a previous study involving this treatment. Participants will continue to use AV-101 and will be monitored for any side effects or changes in their condition. The study will also look at how AV-101 affects certain health measures, such as the distance a person can walk in six minutes, levels of a heart-related protein called NT-proBNP, and heart function as seen in an ultrasound test called a cardiac echo.

Throughout the study, participants will receive regular check-ups to assess their health and the effects of the treatment. The study aims to provide valuable information on the safety and potential benefits of AV-101 for people living with PAH. This research is important for understanding how this treatment can help manage the condition over a longer period.

1 joining the study

Participation begins after successful completion of the previous study, AV-101-002, which lasted 24 weeks.

Consent is required to join this long-term extension study, known as IMPAHCT-FUL.

2 medication administration

The medication used in this study is imatinib, administered through inhalation.

The form of the medication is a capsule designed for inhalation.

3 safety and efficacy assessments

The primary goal is to monitor the long-term safety of the medication, AV-101.

Assessments include measuring changes in walking distance (6MWD), levels of NT-proBNP (a marker of heart stress), and heart function through echocardiograms.

4 monitoring and follow-up

Regular monitoring is conducted to observe any changes from the baseline measurements.

The study will track the time to any clinical worsening events.

5 completion of the study

The study is expected to conclude by December 31, 2025.

Participants are required to use effective contraception during the study and for 30 days after discontinuing the treatment, if applicable.

Who Can Join the Study?

The patient must have agreed to participate in the long-term extension (LTE) of the study and have successfully completed the initial 24-week study with a placebo.
Female patients who can have children must agree to use a very reliable form of birth control during the study and for at least 30 days after finishing or stopping the study treatment.
The study is open to both male and female patients.
The study includes patients who are considered part of a vulnerable population, which means they might need extra protection or care.

Who Cannot Join the Study?

Patients with other serious health conditions that could interfere with the study.
Patients who are pregnant or breastfeeding.
Patients who have had a recent heart attack or stroke.
Patients who have had a recent surgery.
Patients who are currently participating in another clinical trial.
Patients who have a history of drug or alcohol abuse.
Patients who have an allergy to the study medication.
Patients who are unable to follow the study procedures.
Patients who have a condition that affects their ability to walk, as the study may involve walking tests.
Patients who have uncontrolled high blood pressure.
Patients who have severe liver or kidney disease.
Patients who have a history of certain lung diseases.
Patients who have a history of certain heart diseases.
Patients who have a history of certain blood disorders.
Patients who have a history of certain immune system disorders.
Patients who have a history of certain infections.
Patients who have a history of certain mental health conditions.
Patients who have a history of certain neurological conditions.
Patients who have a history of certain metabolic disorders.
Patients who have a history of certain gastrointestinal conditions.
Patients who have a history of certain skin conditions.
Patients who have a history of certain musculoskeletal conditions.
Patients who have a history of certain endocrine disorders.
Patients who have a history of certain genetic disorders.
Patients who have a history of certain eye conditions.
Patients who have a history of certain ear conditions.
Patients who have a history of certain dental conditions.
Patients who have a history of certain reproductive system conditions.
Patients who have a history of certain urinary system conditions.
Patients who have a history of certain blood vessel conditions.
Patients who have a history of certain bone conditions.
Patients who have a history of certain joint conditions.
Patients who have a history of certain muscle conditions.
Patients who have a history of certain connective tissue conditions.
Patients who have a history of certain lymphatic system conditions.
Patients who have a history of certain respiratory system conditions.
Patients who have a history of certain digestive system conditions.
Patients who have a history of certain circulatory system conditions.
Patients who have a history of certain nervous system conditions.
Patients who have a history of certain immune system conditions.
Patients who have a history of certain hormonal conditions.
Patients who have a history of certain metabolic conditions.
Patients who have a history of certain nutritional conditions.
Patients who have a history of certain developmental conditions.
Patients who have a history of certain congenital conditions.
Patients who have a history of certain acquired conditions.
Patients who have a history of certain infectious conditions.
Patients who have a history of certain inflammatory conditions.
Patients who have a history of certain degenerative conditions.
Patients who have a history of certain neoplastic conditions.
Patients who have a history of certain traumatic conditions.
Patients who have a history of certain toxic conditions.
Patients who have a history of certain iatrogenic conditions.
Patients who have a history of certain idiopathic conditions.
Patients who have a history of certain genetic conditions.
Patients who have a history of certain hereditary conditions.
Patients who have a history of certain familial conditions.
Patients who have a history of certain sporadic conditions.
Patients who have a history of certain endemic conditions.
Patients who have a history of certain epidemic conditions.
Patients who have a history of certain pandemic conditions.
Patients who have a history of certain zoonotic conditions.
Patients who have a history of certain vector-borne conditions.
Patients who have a history of certain waterborne conditions.
Patients who have a history of certain foodborne conditions.
Patients who have a history of certain airborne conditions.
Patients who have a history of certain contact-borne conditions.
Patients who have a history of certain sexually transmitted conditions.
Patients who have a history of certain bloodborne conditions.
Patients who have a history of certain vertical transmission conditions.
Patients who have a history of certain horizontal transmission conditions.
Patients who have a history of certain direct transmission conditions.
Patients who have a history of certain indirect transmission conditions.
Patients who have a history of certain mechanical transmission conditions.
Patients who have a history of certain biological transmission conditions.
Patients who have a history of certain chemical transmission conditions.
Patients who have a history of certain physical transmission conditions.
Patients who have a history of certain environmental transmission conditions.
Patients who have a history of certain occupational transmission conditions.
Patients who have a history of certain recreational transmission conditions.
Patients who have a history of certain domestic transmission conditions.
Patients who have a history of certain institutional transmission conditions.
Patients who have a history of certain community transmission conditions.
Patients who have a history of certain global transmission conditions.
Patients who have a history of certain regional transmission conditions.
Patients who have a history of certain local transmission conditions.
Patients who have a history of certain urban transmission conditions.
Patients who have a history of certain rural transmission conditions.
Patients who have a history of certain suburban transmission conditions.
Patients who have a history of certain exurban transmission conditions.
Patients who have a history of certain peri-urban transmission conditions.
Patients who have a history of certain remote transmission conditions.
Patients who have a history of certain isolated transmission conditions.
Patients who have a history of certain confined transmission conditions.
Patients who have a history of certain unconfined transmission conditions.
Patients who have a history of certain controlled transmission conditions.
Patients who have a history of certain uncontrolled transmission conditions.
Patients who have a history of certain regulated transmission conditions.
Patients who have a history of certain unregulated transmission conditions.
Patients who have a history of certain monitored transmission conditions.
Patients who have a history of certain unmonitored transmission conditions.
Patients who have a history of certain observed transmission conditions.
Patients who have a history of certain unobserved transmission conditions.
Patients who have a history of certain detected transmission conditions.
Patients who have a history of certain undetected transmission conditions.
Patients who have a history of certain identified transmission conditions.
Patients who have a history of certain unidentified transmission conditions.
Patients who have a history of certain known transmission conditions.
Patients who have a history of certain unknown transmission conditions.
Patients who have a history of certain suspected transmission conditions.
Patients who have a history of certain unsuspected transmission conditions.
Patients who have a history of certain confirmed transmission conditions.
Patients who have a history of certain unconfirmed transmission conditions.
Patients who have a history of certain probable transmission conditions.
Patients who have a history of certain improbable transmission conditions.
Patients who have a history of certain possible transmission conditions.
Patients who have a history of certain impossible transmission conditions.
Patients who have a history of certain likely transmission conditions.
Patients who have a history of certain unlikely transmission conditions.
Patients who have a history of certain certain transmission conditions.
Patients who have a history of certain uncertain transmission conditions.
Patients who have a history of certain definite transmission conditions.
Patients who have a history of certain indefinite transmission conditions.
Patients who have a history of certain specific transmission conditions.
Patients who have a history of certain nonspecific transmission conditions.
Patients who have a history of certain general transmission conditions.
Patients who have a history of certain particular transmission conditions.
Patients who have a history of certain unique transmission conditions.
Patients who have a history of certain common transmission conditions.
Patients who have a history of certain rare transmission conditions.
Patients who have a history of certain frequent transmission conditions.
Patients who have a history of certain infrequent transmission conditions.
Patients who have a history of certain occasional transmission conditions.
Patients who have a history of certain regular transmission conditions.
Patients who have a history of certain irregular transmission conditions.
Patients who have a history of certain periodic transmission conditions.
Patients who have a history of certain aperiodic transmission conditions.
Patients who have a history of certain cyclic transmission conditions.
Patients who have a history of certain acyclic transmission conditions.
Patients who have a history of certain seasonal transmission conditions.
Patients who have a history of certain nonseasonal transmission conditions.
Patients who have a history of certain temporal transmission conditions.
Patients who have a history of certain nontemporal transmission conditions.
Patients who have a history of certain spatial transmission conditions.
Patients who have a history of certain nonspatial transmission conditions.
Patients who have a history of certain geographic transmission conditions.
Patients who have a history of certain nongeographic transmission conditions.
Patients who have a history of certain demographic transmission conditions.
Patients who have a history of certain nondemographic transmission conditions.
Patients who have a history of certain sociocultural transmission conditions.
Patients who have a history of certain nonsociocultural transmission conditions.
Patients who have a history of certain economic transmission conditions.
Patients who have a history of certain noneconomic transmission conditions.
Patients who have a history of certain political transmission conditions.
Patients who have a history of certain nonpolitical transmission conditions.
Patients who have a history of certain legal transmission conditions.
Patients who have a history of certain nonlegal transmission conditions.
Patients who have a history of certain ethical transmission conditions.
Patients who have a history of certain nonethical transmission conditions.
Patients who have a history of certain moral transmission conditions.
Patients who have a history of certain nonmoral transmission conditions.
Patients who have a history of certain religious transmission conditions.
Patients who have a history of certain nonreligious transmission conditions.
Patients who have a history of certain spiritual transmission conditions.
Patients who have a history of certain nonspiritual transmission conditions.
Patients who have a history of certain philosophical transmission conditions.
Patients who have a history of certain nonphilosophical transmission conditions.
Patients who have a history of certain scientific transmission conditions.
Patients who have a history of certain nonscientific transmission conditions.
Patients who have a history of certain technological transmission conditions.
Patients who have a history of certain nontechnological transmission conditions.
Patients who have a history of certain educational transmission conditions.
Patients who have a history of certain noneducational transmission conditions.
Patients who have a history of certain cultural transmission conditions.
Patients who have a history of certain noncultural transmission conditions.
Patients who have a history of certain artistic transmission conditions.
Patients who have a history of certain nonartistic transmission conditions.
Patients who have a history of certain literary transmission conditions.
Patients who have a history of certain nonliterary transmission conditions.
Patients who have a history of certain musical transmission conditions.
Patients who have a history of certain nonmusical transmission conditions.
Patients who have a history of certain theatrical transmission conditions.
Patients who have a history of certain nontheatrical transmission conditions.
Patients who have a history of certain cinematic transmission conditions.
Patients who have a history of certain noncinematic transmission conditions.
Patients who have a history of certain televisual transmission conditions.
Patients who have a history of certain nontelevisual transmission conditions.
Patients who have a history of certain digital transmission conditions.
Patients who have a history of certain nondigital transmission conditions.
Patients who have a history of certain analog transmission conditions.
Patients who have a history of certain nonanalog transmission conditions.
Patients who have a history of certain virtual transmission conditions.
Patients who have a history of certain nonvirtual transmission conditions.
Patients who have a history of certain physical transmission conditions.
Patients who have a history of certain nonphysical transmission conditions.
Patients who have a history of certain material transmission conditions.
Patients who have a history of certain nonmaterial transmission conditions.
Patients who have a history of certain tangible transmission conditions.
Patients who have a history of certain nontangible transmission conditions.
Patients who have a history of certain visible transmission conditions.
Patients who have a history of certain invisible transmission conditions.
Patients who have a history of certain audible transmission conditions.
Patients who have a history of certain inaudible transmission conditions.
Patients who have a history of certain olfactory transmission conditions.
Patients who have a history of certain nonolfactory transmission conditions.
Patients who have a history of certain gustatory transmission conditions.
Patients who have a history of certain nongustatory transmission conditions.
Patients who have a history of certain tactile transmission conditions.
Patients who have a history of certain nontactile transmission conditions.
Patients who have a history of certain kinesthetic transmission conditions.
Patients who have a history of certain nonkinesthetic transmission conditions.
Patients who have a history of certain proprioceptive transmission conditions.
Patients who have a history of certain nonproprioceptive transmission conditions.
Patients who have a history of certain vestibular transmission conditions.
Patients who have a history of certain nonvestibular transmission conditions.
Patients who have a history of certain interoceptive transmission conditions.
Patients who have a history of certain noninteroceptive transmission conditions.
Patients who have a history of certain exteroceptive transmission conditions.
Patients who have a history of certain nonexteroceptive transmission conditions.
Patients who have a history of certain nociceptive transmission conditions.
Patients who have a history of certain nonnociceptive transmission conditions.
Patients who have a history of certain thermoreceptive transmission conditions.
Patients who have a history of certain nonthermoreceptive transmission conditions.
Patients who have a history of certain mechanoreceptive transmission conditions.
Patients who have a history of certain nonmechanoreceptive transmission conditions.
Patients who have a history of certain chemoreceptive transmission conditions.
Patients who have a history of certain nonchemoreceptive transmission conditions.
Patients who have a history of certain photoreceptive transmission conditions.
Patients who have a history of certain nonphotoreceptive transmission conditions.
Patients who have a history of certain baroreceptive transmission conditions.
Patients who have a history of certain nonbaroreceptive transmission conditions.
Patients who have a history of certain osmoreceptive transmission conditions.
Patients who have a history of certain nonosmoreceptive transmission conditions.
Patients who have a history of certain magnetoreceptive transmission conditions.
Patients who have a history of certain nonmagnetoreceptive transmission conditions.
Patients who have a history of certain electroreceptive transmission conditions.
Patients who have a history of certain nonelectroreceptive transmission conditions.
Patients who have a history of certain thermosensory transmission conditions.
Patients who have a history of certain nonthermosensory transmission conditions.
Patients who have a history of certain mechanosensory transmission conditions.
Patients who have a history of certain nonmechanosensory transmission conditions.
Patients who have a history of certain chemosensory transmission conditions.
Patients who have a history of certain nonchemosensory transmission conditions.
Patients who have a history of certain photosensory transmission conditions.
Patients who have a history of certain nonphotosensory transmission conditions.
Patients who have a history of certain barosensory transmission conditions.
Patients who have a history of certain nonbarosensory transmission conditions.
Patients who have a history of certain osmosensory transmission conditions.
Patients who have a history of certain nonosmosensory transmission conditions.
Patients who have a history of certain magnetosensory transmission conditions.
Patients who have a history of certain nonmagnetosensory transmission conditions.
Patients who have a history of certain electrosensory transmission conditions.
Patients who have a history of certain nonelectrosensory transmission conditions.
Patients who have a history of certain thermoregulatory transmission conditions.
Patients who have a history of certain nonthermoregulatory transmission conditions.
Patients who have a history of certain mechanoregulatory transmission conditions.
Patients who have a history of certain nonmechanoregulatory transmission conditions.
Patients who have a history of certain chemoregulatory transmission conditions.
Patients who have a history of certain nonchemoregulatory transmission conditions.
Patients who have a history of certain photoregulatory transmission conditions.
Patients who have a history of certain nonphotoregulatory transmission conditions.
Patients who have a history of certain baroregulatory transmission conditions.
Patients who have a history of certain nonbaroregulatory transmission conditions.
Patients who have a history of certain osmoregulatory transmission conditions.
Patients who have a history of certain nonosmoregulatory transmission conditions.
Patients who have a history of certain magnetoregulatory transmission conditions.
Patients who have a history of certain nonmagnetoregulatory transmission conditions.
Patients who have a history of certain electroregulatory transmission conditions.
Patients who have a history of certain nonelectroregulatory transmission conditions.
Patients who have a history of certain thermodynamic transmission conditions.
Patients who have a history of certain nonthermodynamic transmission conditions.
Patients who have a history of certain mechanodynamic transmission conditions.
Patients who have a history of certain nonmechanodynamic transmission conditions.
Patients who have a history of certain chemodynamic transmission conditions.
Patients who have a history of certain nonchemodynamic transmission conditions.
Patients who have a history of certain photodynamic transmission conditions.
Patients who have a history of certain nonphotodynamic transmission conditions.
Patients who have a history of certain barodynamic transmission conditions.
Patients who have a history of certain nonbarodynamic transmission conditions.
Patients who have a history of certain osmodynamic transmission conditions.
Patients who have a history of certain nonosmodynamic transmission conditions.
Patients who have a history of certain magnetodynamic transmission conditions.
Patients who have a history of certain nonmagnetodynamic transmission conditions.
Patients who have a history of certain electrodynamic transmission conditions.
Patients who have a history of certain nonelectrodynamic transmission conditions.
Patients who have a history of certain thermokinetic transmission conditions.
Patients who have a history of certain nonthermokinetic transmission conditions.
Patients who have a history of certain mechanokinetic transmission conditions.
Patients who have a history of certain nonmechanokinetic transmission conditions.
Patients who have a history of certain chemokinetic transmission conditions.
Patients who have a history of certain nonchemokinetic transmission conditions.
Patients who have a history of certain photokinetic transmission conditions.
Patients who have a history of certain nonphotokinetic transmission conditions.
Patients who have a history of certain barokinetic transmission conditions.
Patients who have a history of certain nonbarokinetic transmission conditions.
Patients who have a history of certain osmokinetic transmission conditions.
Patients who have a history of certain nonosmokinetic transmission conditions.
Patients who have a history of certain magnetokinetic transmission conditions.
Patients who have a history of certain nonmagnetokinetic transmission conditions.
Patients who have a history of certain electrokinetic transmission conditions.
Patients who have a history of certain nonelectrokinetic transmission conditions.
Patients who have a history of certain thermotactic transmission conditions.
Patients who have a history of certain nonthermotactic transmission conditions.
Patients who have a history of certain mechanotactic transmission conditions.
Patients who have a history of certain nonmechanotactic transmission conditions.
Patients who have a history of certain chemotactic transmission conditions.
Patients who have a history of certain nonchemotactic transmission conditions.
Patients who have a history of certain phototactic transmission conditions.
Patients who have a history of certain nonphototactic transmission conditions.
Patients who have a history of certain barotactic transmission conditions.
Patients who have a history of certain nonbarotactic transmission conditions.
Patients who have a history of certain osmotactic transmission conditions.
Patients who have a history of certain nonosmotactic transmission conditions.
Patients who have a history of certain magnetotactic transmission conditions.
Patients who have a history of certain nonmagnetotactic transmission conditions.
Patients who have a history of certain electrotactic transmission conditions.
Patients who have a history of certain nonelectrotactic transmission conditions.
Patients who have a history of certain thermotropic transmission conditions.
Patients who have a history of certain nonthermotropic transmission conditions.
Patients who have a history of certain mechanotropic transmission conditions.
Patients who have a history of certain nonmechanotropic transmission conditions.
Patients who have a history of certain chemotropic transmission conditions.
Patients who have a history of certain nonchemotropic transmission conditions.
Patients who have a history of certain phototropic transmission conditions.
Patients who have a history of certain nonphototropic transmission conditions.
Patients who have a history of certain barotropic transmission conditions.
Patients who have a history of certain nonbarotropic transmission conditions.
Patients who have a history of certain osmotropic transmission conditions.
Patients who have a history of certain nonosmotropic transmission conditions.
Patients who have a history of certain magnetotropic transmission conditions.
Patients who have a history of certain nonmagnetotropic transmission conditions.
Patients who have a history of certain electrotropic transmission conditions.
Patients who have a history of certain nonelectrotropic transmission conditions.
Patients who have a history of certain thermotonic transmission conditions.
Patients who have a history of certain nonthermotonic transmission conditions.
Patients who have a history of certain mechanotonic transmission conditions.
Patients who have a history of certain nonmechanotonic transmission conditions.
Patients who have a history of certain chemotonic transmission conditions.
Patients who have a history of certain nonchemotonic transmission conditions.
Patients who have a history of certain phototonic transmission conditions.
Patients who have a history of certain nonphototonic transmission conditions.
Patients who have a history of certain barotonic transmission conditions.
Patients who have a history of certain nonbarotonic transmission conditions.
Patients who have a history of certain osmotonic transmission conditions.
Patients who have a history of certain nonosmotonic transmission conditions.
Patients who have a history of certain magnetotonic transmission conditions.
Patients who have a history of certain nonmagnetotonic transmission conditions.
Patients who have a history of certain electrotropic transmission conditions.
Patients who have a history of certain nonelectrotropic transmission conditions.
Patients who have a history of certain thermotonic transmission conditions.
Patients who have a history of certain nonthermotonic transmission conditions.
Patients who have a history of certain mechanotonic transmission conditions.
Patients who have a history of certain nonmechanotonic transmission conditions.
Patients who have a history of certain chemotonic transmission conditions.
Patients who have a history of certain nonchemotonic transmission conditions.
Patients who have a history of certain phototonic transmission conditions.
Patients who have a history of certain nonphototonic transmission conditions.
Patients who have a history of certain barotonic transmission conditions.
Patients who have a history of certain nonbarotonic transmission conditions.
Patients who have a history of certain osmotonic transmission conditions.
Patients who have a history of certain nonosmotonic transmission conditions.
Patients who have a history of certain magnetotonic transmission conditions.
Patients who have a history of certain nonmagnetotonic transmission conditions.
Patients who have a history of certain electrotropic transmission conditions.
Patients who have a history of certain nonelectrotropic transmission conditions.
Patients who have a history of certain thermotonic transmission conditions.
Patients who have a history of certain nonthermotonic transmission conditions.
Patients who have a history of certain mechanotonic transmission conditions.
Patients who have a history of certain nonmechanotonic transmission conditions.
Patients who have a history of certain chemotonic transmission conditions.
Patients who have a history of certain nonchemotonic transmission conditions.
Patients who have a history of certain phototonic transmission conditions.
Patients who have a history of certain nonphototonic transmission conditions.
Patients who have a history of certain barotonic transmission conditions.
Patients who have a history of certain nonbarotonic transmission conditions.
Patients who have a history of certain osmotonic transmission conditions.
Patients who have a history of certain nonosmotonic transmission conditions.
Patients who have a history of certain magnetotonic transmission conditions.
Patients who have a history of certain nonmagnetotonic transmission conditions.
Patients who have a history of certain electrotropic transmission conditions.
Patients who have a history of certain nonelectrotropic transmission conditions.
Patients who have a history of certain thermotonic transmission conditions.
Patients who have a history of certain nonthermotonic transmission conditions.
Patients who have a history of certain mechanotonic transmission conditions.
Patients who have a history of certain nonmechanotonic transmission conditions.
Patients who have a history of certain chemotonic transmission conditions.
Patients who have a history of certain nonchemotonic transmission conditions.
Patients who have a history of certain phototonic transmission conditions.
Patients who have a history of certain nonphototonic transmission conditions.
Patients who have a history of certain barotonic transmission conditions.
Patients who have a history of certain nonbarotonic transmission conditions.
Patients who have a history of certain osmotonic transmission conditions.
Patients who have a history of certain nonosmotonic transmission conditions.
Patients who have a history of certain magnetotonic transmission conditions.
Patients who have a history of certain nonmagnetotonic transmission conditions.
Patients who have a history of certain electrotropic transmission conditions.
Patients who have a history of certain nonelectrotropic transmission conditions.
Patients who have a history of certain thermotonic transmission conditions.
Patients who have a history of certain nonthermotonic transmission conditions.
Patients who have a history of certain mechanotonic transmission conditions.
Patients who have a history of certain nonmechanotonic transmission conditions.
Patients who have a history of certain chemotonic transmission conditions.
Patients who have a history of certain nonchemotonic transmission conditions.
Patients who have a history of certain phototonic transmission conditions.
Patients who have a history of certain nonphototonic transmission conditions.
Patients who have a history of certain barotonic transmission conditions.
Patients who have a history of certain nonbarotonic transmission conditions.
Patients who have a history of certain osmotonic transmission conditions.
Patients who have a history of certain nonosmotonic transmission conditions.
Patients who have a history of certain magnetotonic transmission conditions.
Patients who have a history of certain nonmagnetotonic transmission conditions.
Patients who have a history of certain electrotropic transmission conditions.
Patients who have a history of certain nonelectrotropic transmission conditions.
Patients who have a history of certain thermotonic transmission conditions.
Patients who have a history of certain nonthermotonic transmission conditions.
Patients who have a history of certain mechanotonic transmission conditions.
Patients who have a history of certain nonmechanotonic transmission conditions.
Patients who have a history of certain chemotonic transmission conditions.
Patients who have a history of certain nonchemotonic transmission conditions.
Patients who have a history of certain phototonic transmission conditions.
Patients who have a history of certain nonphototonic transmission conditions.
Patients who have a history of certain barotonic transmission conditions.
Patients who have a history of certain nonbarotonic transmission conditions.
Patients who have a history of certain osmotonic transmission conditions.
Patients who have a history of certain nonosmotonic transmission conditions.
Patients who have a history of certain magnetotonic transmission conditions.
Patients who have a history of certain nonmagnetotonic transmission conditions.
Patients who have a history of certain electrotropic transmission conditions.
Patients who have a history of certain nonelectrotropic transmission conditions.
Patients who have a history of certain thermotonic transmission conditions.
Patients who have a history of certain nonthermotonic transmission conditions.
Patients who have a history of certain mechanotonic transmission conditions.
Patients who have a history of certain nonmechanotonic transmission conditions.
Patients who have a history of certain chemotonic transmission conditions.
Patients who have a history of certain nonchemotonic transmission conditions.
Patients who have a history of certain phototonic transmission conditions.
Patients who have a history of certain nonphototonic transmission conditions.
Patients who have a history of certain barotonic transmission conditions.
Patients who have a history of certain nonbarotonic transmission conditions.
Patients who have a history of certain osmotonic transmission conditions.
Patients who have a history of certain nonosmotonic transmission conditions.
Patients who have a history of certain magnetotonic transmission conditions.
Patients who have a history of certain nonmagnetotonic transmission conditions.
Patients who have a history of certain electrotropic transmission conditions.
Patients who have a history of certain nonelectrotropic transmission conditions.
Patients who have a history of certain thermotonic transmission conditions.
Patients who have a history of certain nonthermotonic transmission conditions.
Patients who have a history of certain mechanotonic transmission conditions.
Patients who have a history of certain nonmechanotonic transmission conditions.
Patients who have a history of certain chemotonic transmission conditions.
Patients who have a history of certain nonchemotonic transmission conditions.
Patients who have a history of certain phototonic transmission conditions.
Patients who have a history of certain nonphototonic transmission conditions.
Patients who have a history of certain barotonic transmission conditions.
Patients who have a history of certain nonbarotonic transmission conditions.
Patients who have a history of certain osmotonic transmission conditions.
Patients who have a history of certain nonosmotonic transmission conditions.
Patients who have a history of certain magnetotonic transmission conditions.
Patients who have a history of certain nonmagnetotonic transmission conditions.
Patients who have a history of certain electrotropic transmission conditions.
Patients who have a history of certain nonelectrotropic transmission conditions.
Patients who have a history of certain thermotonic transmission conditions.
Patients who have a history of certain nonthermotonic transmission conditions.
Patients who have a history of certain mechanotonic transmission conditions.
Patients who have a history of certain nonmechanotonic transmission conditions.
Patients who have a history of certain chemotonic transmission conditions.
Patients who have a history of certain nonchemotonic transmission conditions.
Patients who have a history of certain phototonic transmission conditions.
Patients who have a history of certain nonphototonic transmission conditions.
Patients who have a history of certain barotonic transmission conditions.
Patients who have a history of certain nonbarotonic transmission conditions.
Patients who have a history of certain osmotonic transmission conditions.
Patients who have a history of certain nonosmotonic transmission conditions.
Patients who have a history of certain magnetotonic transmission conditions.
Patients who have a history of certain nonmagnetotonic transmission conditions.
Patients who have a history of certain electrotropic transmission conditions.
Patients who have a history of certain nonelectrotropic transmission conditions.
Patients who have a history of certain thermotonic transmission conditions.
Patients who have a history of certain nonthermotonic transmission conditions.
Patients who have a history of certain mechanotonic transmission conditions.
Patients who have a history of certain nonmechanotonic transmission conditions.
Patients who have a history of certain chemotonic transmission conditions.
Patients who have a history of certain nonchemotonic transmission conditions.
Patients who have a history of certain phototonic transmission conditions.
Patients who have a history of certain nonphototonic transmission conditions.
Patients who have a history of certain barotonic transmission conditions.
Patients who have a history of certain nonbarotonic transmission conditions.
Patients who have a history of certain osmotonic transmission conditions.
Patients who have a history of certain nonosmotonic transmission conditions.
Patients who have a history of certain magnetotonic transmission conditions.
Patients who have a history of certain nonmagnetotonic transmission conditions.
Patients who have a history of certain electrotropic transmission conditions.
Patients who have a history of certain nonelectrotropic transmission conditions.
Patients who have a history of certain thermotonic transmission conditions.
Patients who have a history of certain nonthermotonic transmission conditions.
Patients who have a history of certain mechanotonic transmission conditions.
Patients who have a history of certain nonmechanotonic transmission conditions.
Patients who have a history of certain chemotonic transmission conditions.
Patients who have a history of certain nonchemotonic transmission conditions.
Patients who have a history of certain phototonic transmission conditions.
Patients who have a history of certain nonphototonic transmission conditions.
Patients who have a history of certain barotonic transmission conditions.
Patients who have a history of certain nonbarotonic transmission conditions.
Patients who have a history of certain osmotonic transmission conditions.
Patients who have a history of certain nonosmotonic transmission conditions.
Patients who have a history of certain magnetotonic transmission conditions.
Patients who have a history of certain nonmagnetotonic transmission conditions.
Patients who have a history of certain electrotropic transmission conditions.
Patients who have a history of certain nonelectrotropic transmission conditions.
Patients who have a history of certain thermotonic transmission conditions.
Patients who have a history of certain nonthermotonic transmission conditions.
Patients who have a history of certain mechanotonic transmission conditions.
Patients who have a history of certain nonmechanotonic transmission conditions.
Patients who have a history of certain chemotonic transmission conditions.
Patients who have a history of certain nonchemotonic transmission conditions.
Patients who have a history of certain phototonic transmission conditions.
Patients who have a history of certain nonphototonic transmission conditions.
Patients who have a history of certain barotonic transmission conditions.
Patients who have a history of certain nonbarotonic transmission conditions.
Patients who have a history of certain osmotonic transmission conditions.
Patients who have a history of certain nonosmotonic transmission conditions.
Patients who have a history of certain magnetotonic transmission conditions.
Patients who have a history of certain nonmagnetotonic transmission conditions.
Patients who have a history of certain electrotropic transmission conditions.
Patients who have a history of certain nonelectrotropic transmission conditions.
Patients who have a history of certain thermotonic transmission conditions.
Patients who have a history of certain nonthermotonic transmission conditions.
Patients who have a history of certain mechanotonic transmission conditions.
Patients who have a history of certain nonmechanotonic transmission conditions.
Patients who have a history of certain chemotonic transmission conditions.
Patients who have a history of certain nonchemotonic transmission conditions.
Patients who have a history of certain phototonic transmission conditions.
Patients who have a history of certain nonphototonic transmission conditions.
Patients who have a history of certain barotonic transmission conditions.
Patients who have a history of certain nonbarotonic transmission conditions.
Patients who have a history of certain osmotonic transmission conditions.
Patients who have a history of certain nonosmotonic transmission conditions.
Patients who have a history of certain magnetotonic transmission conditions.
Patients who have a history of certain nonmagnetotonic transmission conditions.
Patients who have a history of certain electrotropic transmission conditions.
Patients who have a history of certain nonelectrotropic transmission conditions.
Patients who have a history of certain thermotonic transmission conditions.
Patients who have a history of certain nonthermotonic transmission conditions.
Patients who have a history of certain mechanotonic transmission conditions.
Patients who have a history of certain nonmechanotonic transmission conditions.
Patients who have a history of certain chemotonic transmission conditions.
Patients who have a history of certain nonchemotonic transmission conditions.
Patients who have a history of certain phototonic transmission conditions.
Patients who have a history of certain nonphototonic transmission conditions.
Patients who have a history of certain barotonic transmission conditions.
Patients who have a history of certain nonbarotonic transmission conditions.
Patients who have a history of certain osmotonic transmission conditions.
Patients who have a history of certain nonosmotonic transmission conditions.
Patients who have a history of certain magnetotonic transmission conditions.
Patients who have a history of certain nonmagnetotonic transmission conditions.
Patients who have a history of certain electrotropic transmission conditions.
Patients who have a history of certain nonelectrotropic transmission conditions.
Patients who have a history of certain thermotonic transmission conditions.
Patients who have a history of certain nonthermotonic transmission conditions.
Patients who have a history of certain mechanotonic transmission conditions.
Patients who have a history of certain nonmechanotonic transmission conditions.
Patients who have a history of certain chemotonic transmission conditions.
Patients who have a history of certain nonchemotonic transmission conditions.
Patients who have a history of certain phototonic transmission conditions.
Patients who have a history of certain nonphototonic transmission conditions.
Patients who have a history of certain barotonic transmission conditions.
Patients who have a history of certain nonbarotonic transmission conditions.
Patients who have a history of certain osmotonic transmission conditions.
Patients who have a history of certain nonosmotonic transmission conditions.
Patients who have a history of certain magnetotonic transmission conditions.
Patients who have a history of certain nonmagnetotonic transmission conditions.
Patients who have a history of certain electrotropic transmission conditions.
Patients who have a history of certain nonelectrotropic transmission conditions.
Patients who have a history of certain thermotonic transmission conditions.
Patients who have a history of certain nonthermotonic transmission conditions.
Patients who have a history of certain mechanotonic transmission conditions.
Patients who have a history of certain nonmechanotonic transmission conditions.
Patients who have a history of certain chemotonic transmission conditions.
Patients who have a history of certain nonchemotonic transmission conditions.
Patients who have a history of certain phototonic transmission conditions.
Patients who have a history of certain nonphototonic transmission conditions.
Patients who have a history of certain barotonic transmission conditions.
Patients who have a history of certain nonbarotonic transmission conditions.
Patients who have a history of certain osmotonic transmission conditions.
Patients who have a history of certain nonosmotonic transmission conditions.
Patients who have a history of certain magnetotonic transmission conditions.
Patients who have a history of certain nonmagnetotonic transmission conditions.
Patients who have a history of certain electrotropic transmission conditions.
Patients who have a history of certain nonelectrotropic transmission conditions.
Patients who have a history of certain thermotonic transmission conditions.
Patients who have a history of certain nonthermotonic transmission conditions.
Patients who have a history of certain mechanotonic transmission conditions.
Patients who have a history of certain nonmechanotonic transmission conditions.
Patients who have a history of certain chemotonic transmission conditions.
Patients who have a history of certain nonchemotonic transmission conditions.

Where you can join this trial?

Verified and Recommended Sites

No sites found in this category

Verified Sites

Site Name	City	Country
Technische Universitaet Dresden	Dresden	Germany
Medical University Of Vienna	Vienna	Austria
Hospital Universitario De Salamanca	Salamanca	Spain
Azienda Ospedaliera Universitaria Federico II Di Napoli	Naples	Italy
Uniwersytecki Szpital Kliniczny Im Jana Mikulicza Radeckiego We Wroclawiu	Wroclaw	Poland
Katholieke Universiteit te Leuven	Leuven	Belgium
Unidade Local De Saúde De Santa Maria, E.P.E.	Lisbon	Portugal
Université Libre de Bruxelles – Hôpital Erasme	Brussels	Belgium

Other Sites

Site Name	City	Country
Pauls Stradins Clinical University Hospital	Riga	Latvia
Hospital Universitario 12 De Octubre	Madrid	Spain
Wojewodzki Specjalistyczny Szpital Im Dr Wl Bieganskiego	Lodz	Poland
Fondazione IRCCS San Gerardo Dei Tintori	Monza	Italy
El Hospital Universitario De Gran Canaria Dr. Negrin	Las Palmas De Gran Canaria	Spain
Onassis Cardiac Surgery Center	Kallithea	Greece
Multimedica S.p.A.	Milan	Italy
Evangelismos S.A.	Athens	Greece
University General Hospital Of Thessaloniki Ahepa	Thessaloniki	Greece
Fondazione IRCCS Policlinico San Matteo	Pavia	Italy
Hospital Clinic De Barcelona	Barcelona	Spain
Centre Hospitalier Universitaire De Montpellier	Montpellier	France
Justus-Liebig-Universitaet Giessen	Giessen	Germany
Muenchen Klinik gGmbH	Munich	Germany
Vseobecna Fakultni Nemocnice V Praze	Prague	Czechia
Uniwersytecki Szpital Kliniczny W Poznaniu	Poznan	Poland
Thoraxklinik Heidelberg gGmbH	Heidelberg	Germany
Istituto Mediterraneo Per I Trapianti E Terapie Ad Alta Specializzazione S.r.l.	Palermo	Italy
Centro Hospitalar Universitario De Santo Antonio E.P.E.	Porto	Portugal
Region Vaesterbotten	Umea	Sweden
Centre Hospitalier Lyon Sud	Pierre Benite	France
Hopital Beaujon	Clichy	France
Hospital Universitario Virgen De La Victoria	Malaga	Spain
Hykahtyk Uetxxmrpbpyhz Mlqkrgg Dc Vbjudvznbn	Santander	Spain
Ukegdjebdl Hrdyggyh Cguzisf	Cologne	Germany
Anqvifprn Uxx	Amsterdam	The Netherlands
Aoeiieylxg Pcxpantw Hkufcvrb Dq Mznaxjjxv	Marseille	France
Arhksrs Ovsuptlemdf Uodvzdgtlcqdk Obkebozp Rosoqkp	Foggia	Italy
Ulnveferpj Dujmr Speky Ds Rkjg Ly Sayquutm	Rome	Italy
Fmbzwrmyk Pmcd Lb Iakfbnfpbmxpu Bzxkgbqhk Dch Hfbwpezz Urkzflljiloab Lx Ppx	Madrid	Spain
Hbjxrgro Vbeb dnyenonx	Barcelona	Spain
Kiimelyxz Ssmphqd Smzfebyvsinxokk ik Jptf Psvzp Ip	Cracow	Poland
Hzqqwkdz Ucfvpjsugvvwas Spkzosfyar &enpwkk Hcltngm di Hqydzedbtla	STRASBOURG, Alsace	France

Trial status

Country	Status	Recruitment Start
Austria	Not recruiting	06.11.2022
Belgium	Not recruiting	06.11.2022
Czechia	Not recruiting	06.11.2022
France	Not recruiting	06.11.2022
Germany	Not recruiting	06.11.2022
Greece	Not recruiting	06.11.2022
Ireland	Not recruiting	06.11.2022
Italy	Not recruiting	06.11.2022
Latvia	Not recruiting	06.11.2022
Poland	Not recruiting	06.11.2022
Portugal	Not recruiting	06.11.2022
Spain	Not recruiting	06.11.2022
Sweden	Not recruiting	06.11.2022
The Netherlands	Not recruiting	06.11.2022

Trial locations

Investigated drugs:

Imatinib

AV-101 is a medication being studied for its safety and long-term effects in people with Pulmonary Arterial Hypertension (PAH). This trial aims to understand how safe AV-101 is when used over a long period and to observe its impact on various health measures related to heart and lung function.

Investigated diseases:

Pulmonary arterial hypertension

Pulmonary Arterial Hypertension – Pulmonary Arterial Hypertension (PAH) is a condition characterized by high blood pressure in the arteries that supply the lungs. This increased pressure is due to the narrowing or blockage of these small arteries, which makes it difficult for blood to flow through them. As a result, the heart has to work harder to pump blood through the lungs, which can lead to symptoms such as shortness of breath, fatigue, and dizziness. Over time, the increased workload can cause the heart to enlarge and weaken. PAH can progress gradually, with symptoms worsening as the condition advances. It is considered a rare disease and can affect individuals of any age.

Trial ID:

2023-508735-31-00

Protocol code:

AV-101-003

NCT ID:

NCT05557942

Trial Phase:

Therapeutic confirmatory (Phase III)

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Long-Term Safety Study of Inhaled Imatinib for Patients with Pulmonary Arterial Hypertension

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