Cefepime is an antibiotic used in this study to understand how it behaves in the body when administered directly into the peritoneal cavity of patients undergoing automated peritoneal dialysis (APD) without peritonitis. The study aims to determine if the concentration of Cefepime in the blood plasma and dialysate is sufficient to be effective. Researchers are examining how the drug is absorbed, distributed, metabolized, and excreted to assess its effectiveness in this specific method of administration.

Chronic Kidney Disease Stage 5 – This is the most advanced stage of chronic kidney disease, where the kidneys have lost nearly all their ability to function effectively. At this stage, the kidneys are functioning at less than 15% of their normal capacity. Waste products and excess fluid build up in the body, leading to symptoms such as fatigue, swelling, and difficulty concentrating. Patients often require dialysis or a kidney transplant to manage the condition. The progression to this stage is typically gradual, occurring over several years. It is crucial to monitor and manage symptoms to maintain quality of life.

Peritoneal Dialysis – This is a treatment for kidney failure that uses the lining of the abdomen, called the peritoneum, to filter waste from the blood. A cleansing fluid is introduced into the abdominal cavity through a catheter, where it absorbs waste products and excess fluids. After a set period, the fluid is drained, taking the waste with it. This process can be done at home, allowing for more flexibility compared to other dialysis methods. It is typically performed daily and can be done while sleeping or during the day. The procedure helps to maintain the balance of fluids and electrolytes in the body.