This clinical trial is focused on studying the effects of a treatment called Pentaglobin in patients with peritonitis and sepsis. Peritonitis is an inflammation of the lining of the abdomen, often due to infection, while sepsis is a serious condition that occurs when the body’s response to infection causes injury to its own tissues and organs. The treatment being tested, Pentaglobin, is a solution containing immunoglobulins, which are proteins that help the immune system fight infections. The study aims to understand how this treatment can help improve the condition of patients who have undergone procedures to control the source of infection.
Participants in the study will receive the treatment through an intravenous infusion, which means it will be administered directly into the bloodstream. The study will monitor changes in the health of several organs, including the lungs, heart, kidneys, liver, and blood, over a period of seven days after the infection source has been controlled. The goal is to see if Pentaglobin can help reduce the severity of multiple organ failure, a condition where several organs stop working properly, which can occur in severe cases of peritonitis and sepsis.
The study will also track other important outcomes, such as survival rates within 28 and 90 days, and changes in the severity of organ failure by the fifth day of treatment. By understanding these effects, researchers hope to determine the potential benefits of using Pentaglobin in treating these serious conditions. The study is designed to provide valuable insights into personalized medicine approaches for patients with peritonitis and sepsis.



Austria
Germany