This clinical trial is focused on patients undergoing planned surgery for digestive cancer. The study aims to evaluate the effects of a quick dose of corticosteroids, specifically using two medications: Methylprednisolone Viatris and Solumedrol. These medications are given as an injection into a vein. The trial will compare the outcomes of patients receiving these medications to those receiving a placebo, which is a substance with no active drug.

The purpose of the study is to understand if a pre-surgery dose of corticosteroids can reduce the risk of major complications after surgery. Participants will be randomly assigned to receive either the corticosteroid treatment or a placebo before their surgery. The study will monitor the occurrence of any significant complications within 30 days after the surgery. Additionally, the study will look at other factors such as overall survival, disease-free survival, and the frequency of infections after surgery.

Throughout the study, the safety of the treatment will be closely observed, with particular attention to side effects like high blood sugar and issues with electrolytes, which are minerals in the blood that help with various body functions. The study will also assess how well surgical wounds heal by checking them 30 days after the surgery. The trial is expected to continue until November 2026, with the goal of providing valuable insights into the benefits of corticosteroids in surgical oncology for digestive cancer.