HepaStem is a therapy that involves using special cells derived from the liver. These cells are designed to help repair and regenerate damaged liver tissue. In this clinical trial, the focus is on understanding how safe HepaStem is for patients over a long period after they have received it in a previous study. The therapy aims to support liver function and improve the health of patients with liver conditions by providing the liver with the necessary cells to aid in its healing process.

Urea Cycle Disorders – Urea Cycle Disorders are a group of genetic conditions that affect the body’s ability to remove waste nitrogen. This occurs due to a deficiency in one of the enzymes in the urea cycle, leading to an accumulation of ammonia in the blood. Ammonia is toxic, especially to the brain, and can cause neurological problems. Symptoms can include vomiting, lethargy, and in severe cases, coma. The progression of the disease can vary, with some individuals experiencing symptoms shortly after birth, while others may not show signs until later in life. The severity of the condition depends on the specific enzyme deficiency and its impact on the urea cycle.

Crigler-Najjar Syndrome – Crigler-Najjar Syndrome is a rare genetic disorder that affects the metabolism of bilirubin, a substance produced by the normal breakdown of red blood cells. The condition is characterized by a deficiency in the enzyme responsible for converting bilirubin into a form that can be easily excreted from the body. As a result, bilirubin accumulates in the blood, leading to jaundice, which is a yellowing of the skin and eyes. There are two types of Crigler-Najjar Syndrome, with Type 1 being more severe than Type 2. The disease progresses with persistent jaundice and can lead to neurological complications if bilirubin levels become too high. The severity and progression of symptoms can vary between individuals.

Fibroinflammatory Liver Diseases – Fibroinflammatory Liver Diseases encompass a range of conditions characterized by inflammation and fibrosis of the liver tissue. These diseases can result from various causes, including chronic infections, autoimmune disorders, and prolonged exposure to toxins. The inflammation leads to the activation of liver cells that produce fibrous tissue, causing scarring and affecting liver function. Over time, the liver may become stiff and less able to perform its normal functions. Symptoms can include fatigue, abdominal pain, and jaundice. The progression of these diseases can lead to significant liver damage if the underlying cause is not addressed.