SGM-101 is a specialized imaging agent that combines an antibody (targeting a specific protein called carcinoembryonic antigen) with a fluorescent dye. This medication is designed to help surgeons better see colorectal cancer that has spread to the brain during surgery. When given to patients before surgery, it attaches to cancer cells and makes them glow under special lighting, helping doctors to identify and remove cancer tissue more precisely.

Brain Metastases – A condition where cancer cells spread from their original site to the brain, forming new tumors. These secondary tumors develop when cancer cells break away from the primary tumor, travel through the bloodstream or lymphatic system, and establish themselves in brain tissue. Brain metastases commonly originate from cancers in other parts of the body, such as colorectal cancer, lung cancer, or breast cancer. The metastatic tumors can develop in any part of the brain and may be single or multiple. The growth of these tumors can affect normal brain function by putting pressure on or damaging surrounding brain tissue.

Colorectal Cancer – A cancer that starts in the colon or rectum, parts of the large intestine. It typically begins as small, benign clumps of cells called polyps that form on the inner lining of the colon or rectum. Over time, some of these polyps can become cancerous and grow into the wall of the colon or rectum. The cancer cells can then spread to nearby tissues and, in some cases, travel to other parts of the body through the blood or lymphatic system.