This clinical trial is focused on studying the effects of a new treatment for dry eye disease, a condition where the eyes do not produce enough tears or the tears evaporate too quickly, leading to discomfort and vision problems. The study will test the use of insulin eye drops to see if they can help manage dry eye symptoms in patients who are already using medications called topical hypotensors, which are often used to treat conditions like ocular hypertension or glaucoma. The trial will compare the effects of insulin eye drops to a placebo, which in this case is artificial tears.

The purpose of the study is to evaluate how effective and safe insulin eye drops are in controlling dry eye disease. Participants will be asked to use the eye drops over a period of six months. During this time, researchers will monitor changes in symptoms and other eye health indicators, such as corneal staining, which is a test to check for damage on the surface of the eye, and conjunctival hyperemia, which refers to redness of the eye. The study will also look at how well the tear film, the thin layer of fluid covering the eye, holds together over time.

Throughout the study, participants will have regular check-ups to assess their eye health and any changes in their condition. The trial will also track any side effects experienced by participants and how well they adhere to their existing hypotensive treatment. The study aims to provide valuable information on whether insulin eye drops can be a beneficial treatment option for those suffering from dry eye disease while using topical hypotensors.