Cannabidiol (CBD) is a natural compound found in the cannabis plant. It is often used for its potential calming effects and is being studied for its ability to help reduce anxiety symptoms. In this clinical trial, CBD is being given to participants for two weeks to see if it can help ease anxiety symptoms before they start other treatments for anxiety or PTSD. The goal is to see if CBD can make these symptoms more manageable for people who work in high-stress jobs, like those in uniformed services in the Netherlands.

Post-Traumatic Stress Disorder (PTSD) – PTSD is a psychological disorder that can develop after experiencing or witnessing a traumatic event. It is characterized by persistent and intrusive memories of the trauma, which can lead to severe emotional distress. Individuals with PTSD may experience flashbacks, nightmares, and severe anxiety. They often avoid situations or stimuli that remind them of the traumatic event. Over time, PTSD can lead to changes in mood and cognition, including feelings of detachment and negative thoughts about oneself or the world. The disorder can also cause heightened arousal responses, such as being easily startled or having difficulty sleeping.

Anxiety Disorders – Anxiety disorders encompass a range of mental health conditions characterized by excessive fear or worry. These disorders can manifest as generalized anxiety disorder, panic disorder, social anxiety disorder, and specific phobias, among others. Individuals with anxiety disorders often experience intense, prolonged feelings of nervousness or dread. Physical symptoms may include increased heart rate, sweating, trembling, and fatigue. Anxiety disorders can interfere with daily activities and relationships, as the fear or worry can be overwhelming and difficult to control. The progression of these disorders varies, with symptoms potentially fluctuating in intensity over time.