Ongoing Clinical Trials for Peritoneal Abscess
There is currently 1 ongoing clinical trial investigating new approaches to prevent peritoneal abscess, specifically focusing on preventing abscesses after surgery for complicated appendicitis. This trial is being conducted in the Netherlands and involves the use of antibiotic lavage during surgery to reduce the risk of infection and abscess formation.
Clinical trial locations
Study on Using Gentamicin and Clindamycin to Prevent Abscesses After Surgery for Complicated Appendicitis in Patients
This clinical trial is investigating a new method to prevent abscesses from forming in the abdominal area after surgery for complicated appendicitis. The trial focuses on using two antibiotics, gentamicin and clindamycin, to wash the abdominal cavity during surgery.
Who can participate:
- Patients who are 8 years old or older
- Those with a diagnosis of acute appendicitis, with or without signs of complications
- Patients undergoing laparoscopic appendectomy, which is a minimally invasive surgery using small cuts and a camera to remove the appendix
- Cases where complicated appendicitis is confirmed during surgery
- Both male and female patients are eligible
- Patients must be able to provide signed written consent, meaning they understand and agree to participate in the study
Who cannot participate:
- Patients with known allergies to gentamicin or clindamycin, the antibiotics used in the study
- Those with a history of severe allergic reactions to any medications
- Pregnant or breastfeeding women, as the treatment might affect the baby
- Patients with other serious health conditions that could interfere with the study results
- Those unable to follow study procedures, such as attending appointments or taking medications as directed
- Patients already participating in another clinical trial
Main focus of the trial:
The study aims to determine whether washing the abdominal area with gentamicin and clindamycin during surgery can reduce the risk of developing an intra-abdominal abscess by at least 50%. An intra-abdominal abscess is a collection of pus that can form after surgery and lead to serious complications. After the standard laparoscopic appendectomy, the surgical team will perform an antibiotic wash by applying the two antibiotics directly to the abdominal cavity for 3 minutes.
Participants will be monitored for 30 days after surgery specifically for signs of abscess formation. Additional monitoring will continue for up to 90 days to check for wound infections, the need for further treatment, and overall recovery and quality of life. The study is expected to continue until 2027, with recruitment beginning in 2025.
Investigational drugs:
Gentamicin is an aminoglycoside antibiotic that works by stopping bacteria from making proteins they need to survive. In this trial, it is applied directly to the abdominal area during surgery to help prevent infections.
Clindamycin is a lincosamide antibiotic that also works by preventing bacteria from producing essential proteins. It is used together with gentamicin in the antibiotic wash to further reduce the chance of infection and abscess formation after the appendix is removed.
Summary
Currently, there is only one active clinical trial specifically addressing peritoneal abscess prevention. This trial is being conducted in the Netherlands and focuses on a specific surgical situation: preventing abscesses after surgery for complicated appendicitis. The approach being tested involves using two well-established antibiotics, gentamicin and clindamycin, in a new way by washing the abdominal cavity during surgery rather than only giving antibiotics through standard routes.
The trial accepts both children and adults, with participants as young as 8 years old eligible to join. The study will run until 2027, giving researchers time to gather meaningful data on whether this antibiotic lavage technique can effectively reduce the occurrence of post-surgical abscesses. This research may provide surgeons with a new tool to improve outcomes for patients undergoing appendectomy for complicated cases.