Infantile apnoea – Basic Information

Go back

Infantile apnoea is a breathing condition that causes babies to stop breathing for brief periods, often accompanied by a slowed heart rate or changes in skin colour. This condition is more common in premature babies and usually resolves on its own as the infant’s body matures, though it can be concerning for parents and requires careful monitoring in hospital settings.

Understanding How Common Infantile Apnoea Is

Infantile apnoea affects many babies, particularly those born prematurely. The condition’s frequency depends heavily on how early a baby is born. Understanding these patterns helps families know what to expect during their baby’s early weeks and months of life.[7]

Among premature infants, the rates are striking. More than 60 percent of babies born at 28 weeks or earlier experience apnoea episodes. For infants born between 30 and 31 weeks, about half will have breathing pauses. The numbers drop as gestational age increases, with 14 percent of babies born at 32 to 33 weeks affected, and only 10 percent of those born at 34 to 35 weeks experiencing the condition.[7]

While infantile apnoea is far more common in preterm babies, it can occasionally occur in full-term infants as well. In these cases, doctors investigate other possible causes since the condition is much rarer when a baby has had the full pregnancy term to develop. The overall prevalence in infants remains somewhat unclear, though between one and five percent of all children experience some form of sleep apnoea.[8]

Most babies who develop apnoea do so in specialized hospital units where continuous monitoring catches episodes quickly. This allows healthcare teams to respond immediately when breathing pauses occur. The condition typically appears within the first week of life for premature babies.[7]

What Causes Babies to Stop Breathing

The root causes of infantile apnoea vary depending on the baby’s gestational age and overall health. For premature infants, the primary issue stems from an underdeveloped respiratory system. Their bodies simply aren’t ready to manage continuous breathing on their own because the breathing control centres in the brain haven’t finished maturing.[1]

The breathing centre in the brainstem (the lower part of the brain that connects to the spinal cord) normally sends steady signals to breathing muscles. In premature babies, this centre hasn’t developed enough to send reliable, consistent signals. This immaturity means the baby’s body doesn’t always remember to breathe, especially during sleep.[3]

Birth complications can also trigger apnoea episodes. Babies who experience birth asphyxia (lack of oxygen during delivery) or whose mothers took certain medications during pregnancy may have breathing difficulties in their first days of life. These situations can temporarily affect the newborn’s ability to breathe regularly.[1]

Beyond prematurity, many other medical conditions can cause apnoea in infants. Infections such as those affecting the urinary system, lungs, or brain can disrupt normal breathing patterns. Heart problems that reduce blood flow to the brain may prevent proper breathing signals from reaching the respiratory muscles.[2]

Digestive issues contribute to some cases as well. When stomach contents and acid flow backward into the oesophagus (the tube connecting the mouth to the stomach), a condition called gastro-oesophageal reflux, it can trigger breathing pauses. The discomfort and irritation from reflux may cause the baby’s airway to react by temporarily stopping breath.[7]

Physical abnormalities in the face, jaw, or airways can create obstructions that make breathing difficult. Babies born with certain genetic conditions like Down syndrome or Pierre Robin sequence often have structural differences that narrow their airways. Even the position of a baby’s head and neck can block airflow if not properly aligned.[8]

Chemical imbalances in the blood also play a role. Low blood sugar, abnormal calcium levels, or problems with sodium balance can all interfere with the body’s respiratory drive. Temperature regulation matters too, as both being too cold and too hot can trigger apnoea episodes.[7]

Which Babies Face Higher Risk

Certain factors increase the likelihood that a baby will experience apnoea. Recognizing these risk factors helps healthcare providers identify infants who need closer monitoring and earlier intervention when needed.

Premature birth stands as the single biggest risk factor. The earlier a baby is born, the greater the chances of apnoea developing. This happens because the nervous system continues developing throughout pregnancy, with the final weeks being crucial for respiratory control maturity. Babies born before 37 weeks simply haven’t had enough time to develop reliable breathing patterns.[3]

Low birth weight increases risk regardless of gestational age. Smaller babies, whether born early or at term, face more challenges with maintaining stable breathing. Their tiny bodies have less reserve to handle the demands of continuous respiration.[3]

Babies with certain medical conditions face elevated risk. Those with cerebral palsy, Down syndrome, sickle cell disease, or abnormalities in skull or facial structure are more prone to breathing difficulties. These conditions can affect either the physical airways or the neurological signals needed for breathing.[3]

A family history of sleep apnoea raises concern. When parents or siblings have experienced breathing disorders during sleep, infants in that family may carry similar tendencies. This genetic component suggests some families have inherited traits affecting respiratory control or airway structure.[3]

Exposure to certain environmental factors increases risk as well. Babies whose mothers smoked during pregnancy show higher rates of central apnoea. The smoke exposure appears to affect the developing respiratory control systems in ways that persist after birth.[8]

Being overweight or having obesity also contributes to risk. Extra tissue around the neck and throat can narrow airways, making it harder for air to pass through during sleep. This physical obstruction adds to any underlying breathing control problems.[3]

⚠️ Important
Infantile apnoea should not be confused with sudden infant death syndrome (SIDS). Unlike apnoea, SIDS cannot be predicted or explained by doctors. With apnoea, healthcare providers can often identify the cause and recommend treatments to manage the condition. The two are separate conditions with different characteristics and outcomes.

Recognizing the Signs of Apnoea

Parents and caregivers need to recognize the warning signs of infantile apnoea to seek help promptly. These symptoms can appear suddenly and without warning, making awareness crucial for infant safety.

The most obvious sign is a pause in breathing that lasts 20 seconds or longer. During these episodes, the baby’s chest stops moving and no air flows through the nose or mouth. This complete cessation of breathing is what defines an apnoea event in full-term infants.[2]

Shorter breathing pauses can also signal apnoea when they occur alongside other worrying signs. If a baby stops breathing for less than 20 seconds but their heart rate drops or their oxygen levels fall, doctors consider this an apnoea episode requiring attention.[1]

Colour changes in the baby’s skin provide important clues. During an apnoea episode, the skin may turn blue or extremely pale, a condition called cyanosis. This bluish tint often appears most noticeably around the lips and mouth, indicating that oxygen isn’t reaching the body’s tissues properly.[2]

The heart rate slows significantly during apnoea episodes. Normal newborn heart rates hover around 140 beats per minute, but during apnoea, the rate can drop below 80 beats per minute. This slowing, called bradycardia, happens because the body isn’t getting enough oxygen and the heart compensates by slowing down.[10]

Some babies become limp or show marked loss of muscle tone during episodes. This floppiness, known as hypotonia, occurs as the body struggles with inadequate oxygen. The infant may appear unable to hold normal postures or movements.[1]

Breathing sounds can change as well. Parents might hear gasping, choking, snorting, or noisy breathing. Persistent snoring night after night is particularly concerning in infants, as babies typically don’t snore. These sounds suggest the airways are partially blocked or that the baby is struggling to breathe.[8]

During daytime hours, affected babies often show signs of poor sleep quality. They may be unusually sleepy, irritable, or have difficulty staying alert. Feeding problems can emerge as babies struggle to coordinate breathing with sucking and swallowing. Some infants experience frequent bedwetting related to the breathing disruptions.[22]

It’s important to distinguish true apnoea from normal breathing patterns. Periodic breathing involves brief pauses of three to ten seconds followed by rapid breaths. This pattern is normal in newborns and doesn’t involve colour changes or heart rate drops. True apnoea involves longer pauses and additional concerning signs.[1]

Ways to Prevent Breathing Problems in Infants

While not all cases of infantile apnoea can be prevented, certain measures reduce risk and severity. These preventive strategies focus on optimizing the baby’s environment and overall health.

Avoiding tobacco smoke is crucial. Pregnant women who smoke increase their baby’s risk of developing apnoea. After birth, keeping infants away from secondhand smoke protects their developing respiratory systems. Even minimal smoke exposure can worsen breathing problems in vulnerable babies.[22]

Maintaining proper sleeping positions helps some babies breathe more easily. Sleeping on the back can sometimes cause the tongue to fall backward and block the airway. Side sleeping or slightly elevating the head of the crib may improve airflow in babies prone to obstruction. However, any position changes should only be made under medical guidance to ensure safe sleep practices.[2]

Creating an optimal sleep environment reduces triggers for apnoea. Keeping the room temperature comfortable, between 65 and 68 degrees, helps babies regulate their breathing. Removing allergens like dust, pet dander, and mould prevents nasal congestion that forces mouth breathing and worsens apnoea symptoms.[2]

Regular cleaning of bedding in hot water kills dust mites that can irritate airways. Using allergen-proof covers on pillows and mattresses creates a barrier against these triggers. Running air purifiers with HEPA filters removes airborne particles that could affect breathing.[2]

For babies at risk due to excess weight, working toward a healthy weight through balanced nutrition helps. Serving appropriate portions of fruits, vegetables, and lean proteins while limiting sugary drinks and processed foods supports healthy growth. Physical activity appropriate for the baby’s age strengthens breathing muscles and overall fitness.[2]

Managing underlying medical conditions prevents apnoea related to those illnesses. Treating infections promptly, controlling reflux, and monitoring for heart problems all reduce the likelihood of breathing difficulties. Regular medical checkups catch developing issues before they trigger apnoea episodes.[2]

For premature infants in hospital settings, careful monitoring and early treatment of apnoea prevent complications. Medical teams watch for the first signs of breathing problems and intervene quickly. This proactive approach has greatly improved outcomes for premature babies prone to apnoea.[17]

How the Body’s Normal Processes Change

Understanding what happens inside the body during infantile apnoea helps explain why this condition occurs and how it affects babies. The changes involve both the nervous system and the physical airways.

In healthy babies, breathing happens automatically without conscious thought. The brainstem continuously monitors oxygen and carbon dioxide levels in the blood. When carbon dioxide rises or oxygen drops, the brainstem sends signals to the respiratory muscles. These muscles then contract and relax in a steady rhythm, pulling air into the lungs and pushing it back out.[3]

Three distinct types of apnoea occur based on what goes wrong in this process. Central apnoea happens when the brainstem fails to send breathing signals. The respiratory muscles don’t receive commands to move, so both chest movement and airflow stop simultaneously. This accounts for about 40 percent of apnoea cases in newborns.[7]

In premature babies, central apnoea results from an immature brainstem. The respiratory control centre simply hasn’t developed enough to maintain consistent signalling. It sometimes “forgets” to tell the body to breathe, especially during certain sleep stages. The brainstem also responds poorly to rising carbon dioxide levels that would normally trigger breathing.[3]

Obstructive apnoea occurs when something blocks the airways despite the brain sending proper signals. The chest moves as respiratory muscles try to breathe, but air cannot flow through the blocked passages. This type accounts for about 10 percent of infant apnoea cases.[7]

Obstructions can happen in several ways. The soft tissues at the back of the throat may collapse inward during sleep when muscle tone naturally decreases. In some babies, the airways are simply too narrow from birth due to structural differences. The head and neck position can kink the airway, preventing air passage. Large tonsils, adenoids, or a large tongue can physically block the breathing passages.[8]

Mixed apnoea combines both central and obstructive elements. Typically, a period of central apnoea occurs first, followed by airway obstruction as the baby tries to resume breathing. This is the most common type in premature infants, accounting for about 50 percent of cases. Short apnoea episodes tend to be purely central, while longer episodes usually involve mixed causes.[7]

When breathing stops, oxygen levels in the blood drop while carbon dioxide accumulates. This chemical imbalance affects the heart, causing it to slow down. The reduced oxygen delivery to tissues causes the bluish skin colour that parents notice. The body tries to wake itself up to restart breathing, but this protective mechanism doesn’t always work quickly enough in young infants.[1]

During rapid eye movement (REM) sleep, apnoea episodes occur most frequently. In this sleep stage, muscle tone throughout the body decreases significantly. The reduced tone makes airways more likely to collapse and makes the respiratory muscles less effective. Since babies spend much of their sleep time in REM stages, they face frequent opportunities for apnoea to occur.[3]

The impact extends beyond just breathing mechanics. Repeated drops in oxygen levels can affect brain function and development if severe or prolonged. Growth hormone release depends on reaching deep sleep stages, which apnoea disrupts. The constant partial awakenings prevent babies from getting truly restorative sleep, even though they may appear to sleep many hours.[8]

⚠️ Important
Most infants outgrow apnoea by the time they reach one year of age. As the baby’s nervous system matures and breathing control centres develop, the episodes naturally decrease and eventually stop. The condition resolves on its own in the majority of cases as normal development progresses, though medical supervision remains important during the period when apnoea is present.

Ongoing Clinical Trials on Infantile apnoea

  • Study on Doxapram for Treating Apnea in Preterm Newborns

    Recruiting

    3 1
    Investigated diseases:
    Belgium The Netherlands

References

https://www.ncbi.nlm.nih.gov/books/NBK441969/

https://www.nationwidechildrens.org/conditions/apnea

https://en.wikipedia.org/wiki/Infantile_apnea

https://emedicine.medscape.com/article/800032-overview

https://kidshealth.org/en/parents/aop.html

https://www.mercy.com/health-care-services/maternity-care-birthing-centers/conditions/neonatal-apnea

https://www.rch.org.au/rchcpg/hospital_clinical_guideline_index/apnoea_neonatal/

https://news.childrensmercy.org/sleep-apnea-in-babies/

https://www.childrenshospital.org/conditions/apnea-prematurity

https://www.choa.org/medical-services/apnea

https://emedicine.medscape.com/article/974971-treatment

https://www.mayoclinic.org/diseases-conditions/pediatric-sleep-apnea/diagnosis-treatment/drc-20376199

https://news.childrensmercy.org/sleep-apnea-in-babies/

https://www.nationwidechildrens.org/conditions/apnea

https://www.ncbi.nlm.nih.gov/books/NBK441969/

https://my.clevelandclinic.org/health/diseases/apnea-of-prematurity

https://pmc.ncbi.nlm.nih.gov/articles/PMC8890764/

https://www.rch.org.au/rchcpg/hospital_clinical_guideline_index/apnoea_neonatal/

https://www.nationwidechildrens.org/conditions/apnea

https://theburlingtondentist.com/lifestyle-changes-pediatric-sleep-apnea-in-burlington-ct/

https://www.mayoclinic.org/diseases-conditions/pediatric-sleep-apnea/diagnosis-treatment/drc-20376199

https://www.nhlbi.nih.gov/health/sleep-apnea/children

https://www.drcorthodontics.com/spokane-valley-wa/tips-to-manage-sleep-apnea-in-children/

https://news.childrensmercy.org/sleep-apnea-in-babies/

https://www.rch.org.au/rchcpg/hospital_clinical_guideline_index/apnoea_neonatal/

https://medlineplus.gov/diagnostictests.html

https://www.questdiagnostics.com/

https://www.healthdirect.gov.au/diagnostic-tests

https://www.who.int/health-topics/diagnostics

https://www.yalemedicine.org/clinical-keywords/diagnostic-testsprocedures

https://www.nibib.nih.gov/science-education/science-topics/rapid-diagnostics

https://www.health.harvard.edu/diagnostic-tests-and-medical-procedures

https://www.roche.com/stories/terminology-in-diagnostics

FAQ

Is infantile apnoea the same as sudden infant death syndrome (SIDS)?

No, infantile apnoea and SIDS are completely different conditions. Apnoea can be detected, monitored, and often explained by doctors who can identify causes and recommend treatments. SIDS, on the other hand, cannot be predicted or explained, and doctors don’t know why it happens. The two should never be confused or linked together.

Will my baby outgrow apnoea?

Most infants outgrow apnoea by the time they are one year old. As the baby’s brain and nervous system mature and breathing control centres develop fully, the episodes naturally decrease and eventually stop. The condition typically resolves on its own as normal development progresses, particularly in cases of apnoea of prematurity.

What’s the difference between periodic breathing and true apnoea?

Periodic breathing involves brief pauses of 3 to 10 seconds followed by rapid breaths. It’s a normal pattern in newborns that doesn’t involve colour changes or drops in heart rate. True apnoea involves breathing pauses of 20 seconds or longer, or shorter pauses accompanied by slow heart rate, bluish skin colour, or marked limpness. Periodic breathing requires no treatment while apnoea needs medical attention.

How is infantile apnoea diagnosed?

The main diagnostic test is an overnight sleep study called a polysomnogram. During this test, sensors placed on the baby monitor brain waves, heartbeat, breathing patterns, oxygen levels, and muscle activity during different sleep stages. This helps doctors detect problems and identify what type of apnoea is occurring. The test must be done in a sleep lab accredited for children.

Why are premature babies more likely to have apnoea?

Premature babies have underdeveloped respiratory systems because they haven’t had the full pregnancy term to mature. The breathing control centre in their brainstem hasn’t finished developing, so it can’t send reliable, consistent signals to tell the body to breathe. The earlier a baby is born, the more immature these systems are, which is why apnoea affects over 60 percent of babies born at 28 weeks or earlier.

🎯 Key takeaways

  • Infantile apnoea is dramatically more common in premature babies, with rates exceeding 60% in those born before 28 weeks, but decreasing significantly as gestational age increases.
  • There are three distinct types of apnoea – central (brain signals fail), obstructive (airways blocked), and mixed (both combined) – with mixed being most common in premature infants.
  • Brief breathing pauses of 5-10 seconds without colour changes or heart rate drops are normal “periodic breathing” and completely different from concerning apnoea episodes.
  • Apnoea episodes often include visible warning signs like bluish skin colour, heart rate dropping below 80 beats per minute, and marked limpness that parents can learn to recognize.
  • The condition is NOT the same as SIDS – apnoea can be explained, monitored, and treated by doctors, while SIDS remains unpredictable and unexplainable.
  • Most babies naturally outgrow apnoea by age one as their nervous systems mature, with the breathing control centres developing the ability to send consistent signals.
  • Environmental factors like tobacco smoke exposure during pregnancy and after birth significantly increase a baby’s risk of developing central sleep apnoea.
  • The only way to properly diagnose sleep apnoea in infants is through an overnight sleep study in a pediatric-accredited sleep lab, where specialists monitor multiple body functions simultaneously.