Neurology and Movement Disorders
Clinical research centers on Parkinson’s disease and Multiple System Atrophy, with attention to long-term safety, tolerability, and therapeutic effect in progressive neurodegenerative conditions.
- Parkinson’s disease
- Multiple System Atrophy
- MSA-P subtype
The portfolio includes work related to gene therapy for central nervous system disorders and delivery into brain regions involved in motor control.
Cardiology and Heart Failure
Research also addresses non-ischemic cardiomyopathy and NYHA Class III congestive heart failure, focusing on cardiac function and symptom burden in advanced heart failure.
- Non-ischemic cardiomyopathy
- Congestive heart failure
- NYHA Class III symptoms
These studies reflect interest in intracoronary delivery approaches for cardiovascular disease.
Gene Therapy and Neurologic Delivery
A major area of activity involves AB-1005 and methods for administering therapeutic material to the putamen and other brain targets, with emphasis on precise neurological delivery.
- Intraputaminal administration
- Convection-enhanced delivery (CED)
- iMRI monitoring
Work in this area is linked to disorders with motor and autonomic involvement, where targeted brain delivery is central to treatment development.
Cardiovascular Gene-Based Therapy
The sponsor is active in gene therapy for cardiomyopathy and heart failure, including research on AB-1002 for patients with advanced symptomatic cardiac disease.
- Intracoronary infusion
- Cardiac gene delivery
- Non-ischemic cardiomyopathy
This area combines cardiology and molecular medicine in the setting of structural heart disease.
