Paediatric nephrology
Research activity includes idiopathic steroid-sensitive nephrotic syndrome, with attention to complicated and relapsing disease in children.
- Nephrotic syndrome
- Relapse prevention
- B-cell guided treatment
The clinical focus is on immune-mediated kidney disease and treatment strategies for paediatric patients with persistent or recurrent proteinuria.
Paediatric haematology
The sponsor is involved in studies of relapsed/refractory B-cell acute lymphoblastic leukemia in children and young adults.
- Acute lymphoblastic leukemia
- B-cell precursor disease
- Refractory blood cancers
Its research interest extends to aggressive haematologic malignancies requiring advanced cellular therapies.
Paediatric immunotherapy
Trials include CD19-directed CAR T-cell approaches for B-cell acute lymphoblastic leukemia and related refractory disease settings.
- CAR T-cell therapy
- CD19 targeting
- Cell-based oncology treatment
This area reflects a therapeutic interest in immune-engineered treatments for children and young adults with difficult-to-treat leukemia.
T-cell malignancies
Additional work addresses relapsed/refractory CD7+ T-cell acute lymphoblastic leukemia and lymphoblastic lymphoma.
- T-cell acute lymphoblastic leukemia
- Lymphoblastic lymphoma
- CD7-targeted therapy
The sponsor’s clinical interest includes targeted cellular treatment options for aggressive T-lineage haematologic cancers.
