This study focuses on patients with HER2-positive metastatic colorectal cancer. The treatment combines three medications: trastuzumab deruxtecan (also known as T-DXd), capecitabine, and bevacizumab. Trastuzumab deruxtecan is a targeted therapy that specifically works against cancer cells with high levels of HER2 protein. Capecitabine is an oral chemotherapy drug, while bevacizumab is a medication that affects blood vessel growth in tumors.
The purpose of this research is to evaluate how well these three medications work together when given as an initial treatment for metastatic colorectal cancer. The study will measure how many patients respond to this combination therapy. Treatment will continue for up to 12 months, with regular medical check-ups to monitor the patient’s health and assess how well the treatment is working.
During the study, trastuzumab deruxtecan and bevacizumab will be given through an intravenous infusion, while capecitabine will be taken as tablets by mouth. Patients will receive regular assessments including physical examinations, blood tests, and imaging scans to monitor their response to treatment and check for any side effects.



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