This clinical trial is focused on studying the effects of two medications, aripiprazole and risperidone, in children and adolescents diagnosed with autism spectrum disorder. These medications are commonly used to help manage behavioral problems associated with autism. The purpose of the study is to explore how monitoring the levels of these medications in the body can help reduce or prevent side effects, particularly weight gain, which is a common concern with these treatments.
Participants in the study will be divided into two groups. One group will receive dosing advice based on therapeutic drug monitoring, which means their medication levels will be regularly checked to adjust the dose as needed. The other group will receive the standard care, where the medication is given according to usual clinical practices without additional monitoring. The study will observe changes in body weight and other health indicators over a period of six months, with some assessments continuing up to twelve months.
Throughout the study, various health aspects will be evaluated, including changes in body mass index (BMI), behavior, quality of life, and any side effects. The study will also monitor levels of certain substances in the blood, such as glucose and cholesterol, and check for any involuntary movements. This research aims to provide valuable insights into how these medications can be used more effectively and safely in young individuals with autism spectrum disorder.



Germany
The Netherlands