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Study on the use of oral vancomycin for children with ulcerative colitis

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What is this study about?

This study focuses on Ulcerative Colitis, which is a type of Inflammatory Bowel Disease that causes swelling and irritation in the digestive tract. The research aims to determine the effectiveness of oral vancomycin in managing different forms of this condition in children. This medication is an antibiotic used to treat certain types of infections.

The study examines how patients respond to the treatment by looking at changes in their commensal microbiota, which refers to the helpful bacteria that naturally live inside the gut. Participants will undergo a process to compare their health status and the composition of their intestinal bacteria before starting the vancomycin treatment and after completing it to see if the medicine helps achieve remission, a state where the disease symptoms are gone and the gut is no longer inflamed.

Who Can Join the Study?

  • You must be between 6 and 16 years old.
  • You must have a confirmed diagnosis of atypical ulcerative colitis, which is a type of long-term inflammation in the large intestine that shows unusual patterns, such as affecting only certain parts of the colon or having specific markers in the blood.
  • You may have or not have PSC (primary sclerosing cholangitis), which is a condition that causes inflammation and scarring in the bile ducts in the liver, as seen on a special medical scan called an MRCP.
  • You or your guardian must agree to participate in OVT (oral microbiota transplantation), which is a treatment where beneficial bacteria are taken by mouth to help balance the bacteria in the gut, for at least 3 months.
  • You must not have received OVT in the past.
  • You must be able to swallow capsules.
  • You must not have an active infection, such as clostridium (a type of harmful bacteria) or other bacteria, based on a stool test before starting the treatment.
  • You must not have started any new medications or new standard treatments for IBD (inflammatory bowel disease) within the 4 weeks before starting the treatment.
  • You are allowed to use contraceptives (birth control) or other medications, as long as they are not antibiotics (medicines used to kill bacteria).
  • If you are a healthy participant, you must have no symptoms or suspicion of inflammatory bowel disease but are scheduled to have an endoscopy (a procedure where a doctor uses a small camera on a tube to look inside the body) for other reasons.

Who Cannot Join the Study?

  • People who have Primary Sclerosing Cholangitis (a condition where the bile ducts in the liver become inflamed and scarred) but do not have Ulcerative colitis (a disease that causes swelling and sores in the digestive tract).
  • People who have Crohn’s disease, which is another type of long-term swelling in the digestive system.
  • Children who are under 6 years old.
  • People who have difficulty swallowing capsules (the small pill-shaped containers used for medicine).
  • People who have had an allergic reaction to vancomycin (a specific type of antibiotic used to treat infections) or other medicines similar to it.
  • People who have malignant disease (cancer) or might need a liver transplant (a surgery to replace a diseased liver with a healthy one) in the next 12 months.
  • People who are pregnant.
  • For healthy participants: people with a chronic illness (a health condition that lasts for a long time) that requires taking medicine regularly.
  • For healthy participants: people who have used antibiotics (medicines used to kill bacteria) in the last 6 months.

Where you can join this trial?

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Other Sites

Site Name City Country Status
Pirkanmaan hyvinvointialue Tampere Finland

Want to learn more about this study or check if you can participate? Contact us.

Trial status

Country Status Recruitment Start
Finland Finland
Not yet recruiting
01.04.2026

Trial locations

Investigated drugs:

Vancomycin is an antibiotic taken by mouth that is being tested to see how well it helps manage different types of inflammatory bowel disease in children. The study looks at how this medicine affects the bacteria living in the gut.

Ulcerative colitis – This is a type of long-term inflammation that affects the digestive tract. It specifically targets the lining of the large intestine and the rectum. The condition causes inflammation and small sores called ulcers to develop on the inner surface of these organs. Over time, the inflammation may move along the colon, causing various symptoms. It is characterized by periods where symptoms are active and periods where they are not.

Trial ID:
2025-524543-12-00
Trial Phase:
Therapeutic exploratory (Phase II)

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