MVA-BN Vaccine is a type of vaccine designed to help protect against a virus called Mpox. In this clinical trial, the vaccine is being tested to see how well it works when given as a booster shot. A booster shot is an additional dose of a vaccine given after the initial series of shots to help maintain or increase the body’s immune response. The trial is looking at two different ways of giving the booster shot: either just under the skin (intradermal) or deeper under the skin (subcutaneous). The goal is to see which method helps the body produce a better immune response, which is the body’s way of fighting off infections. This vaccine is being tested in people who have already received the initial vaccination series, as well as in those who have not. The study aims to ensure that the booster shot is safe and effective in providing protection against the Mpox virus.

Monkeypox – Monkeypox is a viral infection caused by the monkeypox virus, which is related to the smallpox virus. It begins with symptoms such as fever, headache, muscle aches, and fatigue. As the disease progresses, a rash develops, often starting on the face and then spreading to other parts of the body. The rash evolves from flat lesions to raised bumps, then to fluid-filled blisters, and finally to scabs. The disease is typically self-limiting, with symptoms lasting for several weeks. Transmission occurs through direct contact with the lesions, bodily fluids, or respiratory droplets of an infected person or animal.