This clinical trial is focused on studying the long-term effects of a medication called Lorundrostat in people with uncontrolled and resistant hypertension, which is a type of high blood pressure that is difficult to manage with standard treatments. The study aims to understand how well Lorundrostat works over time, how safe it is, and how well people can tolerate it. Lorundrostat is taken as a tablet by mouth, and the study will also include a comparison with a placebo to evaluate its effectiveness.

Participants in the study will take Lorundrostat for a period of time to see if it helps maintain lower blood pressure levels. The study will also explore how starting with a dose of 25 mg once daily affects blood pressure and whether it can improve a condition called albuminuria, which involves protein in the urine and can be a sign of kidney problems. The study will include a special part where some participants will stop taking Lorundrostat to see how their blood pressure changes, which helps to understand the medication’s impact better.

The trial is designed to gather information on the long-term safety and effectiveness of Lorundrostat for people with high blood pressure that is hard to control. This information will help determine if Lorundrostat can be a reliable treatment option for managing hypertension in the future. Participants will be monitored throughout the study to ensure their safety and to collect data on how the medication affects their blood pressure and overall health.