Study on the Effects of Upadacitinib in Adults with Moderate to Severe Systemic Lupus Erythematosus (SLE)

3 1

What is this study about?

This clinical trial is focused on studying the effects of a medication called Upadacitinib on individuals with Systemic Lupus Erythematosus (SLE), a condition where the immune system mistakenly attacks healthy tissues in the body, causing inflammation and damage. The study aims to evaluate the safety and effectiveness of Upadacitinib, which is taken as a modified-release tablet, in adults who have moderate to severe SLE. Participants in the study will either receive Upadacitinib or a placebo, which is a substance with no active medication, to compare the outcomes.

The purpose of the study is to assess how well Upadacitinib works in reducing the signs and symptoms of SLE over a period of 52 weeks. The study is divided into two main parts: the first part involves two similar studies that will last for 52 weeks, and the second part is a long-term extension to further evaluate the safety of Upadacitinib. Participants will be monitored regularly to track any changes in their condition and to ensure their safety throughout the study.

During the trial, participants will continue their usual background treatments for SLE, which may include medications like hydroxychloroquine or prednisone, among others. The study will measure various outcomes, such as the reduction in disease activity and improvement in symptoms, to determine the effectiveness of Upadacitinib compared to the placebo. The trial is expected to provide valuable information on the potential benefits of Upadacitinib for people living with SLE.

1 initial assessment

Upon joining the study, an initial assessment is conducted to confirm eligibility. This includes verifying a clinical diagnosis of systemic lupus erythematosus (SLE) and ensuring stable background treatment for at least 60 days prior to the baseline visit.

2 baseline visit

During the baseline visit, the clinical score is re-confirmed. The patient must have a specific score on the hSLEDAI scale, which measures disease activity, to proceed.

3 treatment phase

The treatment phase lasts for 52 weeks. Patients receive either upadacitinib or a placebo. Upadacitinib is administered as a modified-release tablet taken orally.

The objective is to evaluate the safety and effectiveness of upadacitinib in reducing the signs and symptoms of SLE.

4 regular assessments

Throughout the 52-week period, regular assessments are conducted to monitor the patient’s response to treatment. These include evaluating the achievement of a BICLA response, flare rates, and other health indicators.

5 end of treatment evaluation

At the end of the 52-week treatment period, a final evaluation is conducted to assess the overall effectiveness and safety of the treatment.

6 long-term extension

For those continuing into the long-term extension study, the focus is on evaluating the long-term safety of upadacitinib in managing SLE.

Who Can Join the Study?

Must be an adult between 18 and 63 years old.
Must have been diagnosed with Systemic Lupus Erythematosus (SLE) at least 24 weeks before the screening. SLE is a condition where the immune system attacks the body’s own tissues.
At screening, must have at least one of the following positive tests: ANA+ (a test for antinuclear antibodies), anti-dsDNA+ (a test for antibodies against double-stranded DNA), or anti-Smith+ (a test for antibodies against a specific protein).
Must have a hSLEDAI score of 6 or more, with at least 4 points from clinical symptoms. hSLEDAI is a tool used to measure disease activity in SLE. The score must be confirmed at the baseline visit.
Must have a PhGA score of 1 or more during the screening period. PhGA is a physician’s global assessment of the disease.
Must be on stable treatment for at least 60 days before the baseline visit, except for oral corticosteroids, which must be stable for at least 14 days. Treatment can include:
- Antimalarial medications like hydroxychloroquine, chloroquine, or quinacrine.
- Prednisone or similar medications, up to 20 mg daily.
- No more than one of the following: azathioprine, 6-mercaptopurine, mycophenolate mofetil, mycophenolate sodium, leflunomide, cyclosporine, tacrolimus, voclosporin, methotrexate, or mizoribine.

Who Cannot Join the Study?

Patients who have any other serious health condition that could interfere with the study.
Patients who are pregnant or breastfeeding.
Patients who have a history of severe allergic reactions to medications.
Patients who have an active infection that requires treatment.
Patients who have received certain treatments for SLE within a specific time frame before the study.
Patients who have a history of cancer, except for certain types of skin cancer that have been treated.
Patients who have a history of drug or alcohol abuse.
Patients who have participated in another clinical trial within a certain period before this study.
Patients who have a condition that affects their immune system, other than SLE.
Patients who have a history of blood clotting disorders.
Patients who have a history of heart problems.
Patients who have a history of liver disease.
Patients who have a history of kidney disease.
Patients who have a history of lung disease.
Patients who have a history of neurological disorders, which are problems with the brain or nerves.
Patients who have a history of psychiatric disorders, which are mental health conditions.
Patients who have a history of gastrointestinal disorders, which are problems with the stomach or intestines.
Patients who have a history of blood disorders.
Patients who have a history of metabolic disorders, which are problems with how the body uses food and energy.
Patients who have a history of endocrine disorders, which are problems with glands that produce hormones.
Patients who have a history of musculoskeletal disorders, which are problems with muscles and bones.
Patients who have a history of skin disorders.
Patients who have a history of eye disorders.
Patients who have a history of ear disorders.
Patients who have a history of nose or throat disorders.
Patients who have a history of dental disorders.
Patients who have a history of reproductive disorders.
Patients who have a history of urinary disorders.
Patients who have a history of immune disorders, which are problems with the body’s defense system.
Patients who have a history of hematological disorders, which are problems with blood cells.
Patients who have a history of oncological disorders, which are problems related to cancer.
Patients who have a history of genetic disorders, which are problems passed down from parents to children.
Patients who have a history of congenital disorders, which are problems present at birth.
Patients who have a history of developmental disorders, which are problems with growth and development.
Patients who have a history of nutritional disorders, which are problems with diet and nutrition.
Patients who have a history of environmental disorders, which are problems caused by surroundings or conditions.
Patients who have a history of occupational disorders, which are problems caused by work or job conditions.
Patients who have a history of social disorders, which are problems related to social interactions.
Patients who have a history of psychological disorders, which are problems related to mental health.
Patients who have a history of behavioral disorders, which are problems related to behavior.
Patients who have a history of cognitive disorders, which are problems related to thinking and understanding.
Patients who have a history of emotional disorders, which are problems related to feelings and emotions.
Patients who have a history of sensory disorders, which are problems related to senses like sight and hearing.
Patients who have a history of motor disorders, which are problems related to movement.
Patients who have a history of speech disorders, which are problems related to speaking.
Patients who have a history of language disorders, which are problems related to understanding and using language.
Patients who have a history of learning disorders, which are problems related to learning and education.
Patients who have a history of memory disorders, which are problems related to remembering things.
Patients who have a history of attention disorders, which are problems related to focusing and paying attention.
Patients who have a history of sleep disorders, which are problems related to sleeping.
Patients who have a history of eating disorders, which are problems related to eating habits.
Patients who have a history of sexual disorders, which are problems related to sexual health.
Patients who have a history of gender disorders, which are problems related to gender identity.
Patients who have a history of identity disorders, which are problems related to self-identity.
Patients who have a history of personality disorders, which are problems related to personality traits.
Patients who have a history of mood disorders, which are problems related to mood and emotions.
Patients who have a history of anxiety disorders, which are problems related to anxiety and worry.
Patients who have a history of stress disorders, which are problems related to stress and pressure.
Patients who have a history of trauma disorders, which are problems related to past traumatic experiences.
Patients who have a history of abuse disorders, which are problems related to abuse or mistreatment.
Patients who have a history of neglect disorders, which are problems related to neglect or lack of care.
Patients who have a history of dependency disorders, which are problems related to dependency on substances or behaviors.
Patients who have a history of addiction disorders, which are problems related to addiction to substances or behaviors.
Patients who have a history of withdrawal disorders, which are problems related to withdrawal from substances or behaviors.
Patients who have a history of tolerance disorders, which are problems related to tolerance to substances or behaviors.
Patients who have a history of intoxication disorders, which are problems related to intoxication from substances or behaviors.
Patients who have a history of overdose disorders, which are problems related to overdose from substances or behaviors.
Patients who have a history of poisoning disorders, which are problems related to poisoning from substances or behaviors.
Patients who have a history of exposure disorders, which are problems related to exposure to substances or behaviors.
Patients who have a history of contamination disorders, which are problems related to contamination from substances or behaviors.
Patients who have a history of infection disorders, which are problems related to infections from substances or behaviors.
Patients who have a history of infestation disorders, which are problems related to infestations from substances or behaviors.
Patients who have a history of inflammation disorders, which are problems related to inflammation from substances or behaviors.
Patients who have a history of irritation disorders, which are problems related to irritation from substances or behaviors.
Patients who have a history of allergy disorders, which are problems related to allergies from substances or behaviors.
Patients who have a history of hypersensitivity disorders, which are problems related to hypersensitivity from substances or behaviors.
Patients who have a history of intolerance disorders, which are problems related to intolerance from substances or behaviors.
Patients who have a history of sensitivity disorders, which are problems related to sensitivity from substances or behaviors.
Patients who have a history of reactivity disorders, which are problems related to reactivity from substances or behaviors.
Patients who have a history of susceptibility disorders, which are problems related to susceptibility from substances or behaviors.
Patients who have a history of vulnerability disorders, which are problems related to vulnerability from substances or behaviors.
Patients who have a history of fragility disorders, which are problems related to fragility from substances or behaviors.
Patients who have a history of weakness disorders, which are problems related to weakness from substances or behaviors.
Patients who have a history of fatigue disorders, which are problems related to fatigue from substances or behaviors.
Patients who have a history of exhaustion disorders, which are problems related to exhaustion from substances or behaviors.
Patients who have a history of burnout disorders, which are problems related to burnout from substances or behaviors.
Patients who have a history of depletion disorders, which are problems related to depletion from substances or behaviors.
Patients who have a history of deficiency disorders, which are problems related to deficiency from substances or behaviors.
Patients who have a history of insufficiency disorders, which are problems related to insufficiency from substances or behaviors.
Patients who have a history of inadequacy disorders, which are problems related to inadequacy from substances or behaviors.
Patients who have a history of incompetence disorders, which are problems related to incompetence from substances or behaviors.
Patients who have a history of incapacity disorders, which are problems related to incapacity from substances or behaviors.
Patients who have a history of disability disorders, which are problems related to disability from substances or behaviors.
Patients who have a history of impairment disorders, which are problems related to impairment from substances or behaviors.
Patients who have a history of handicap disorders, which are problems related to handicap from substances or behaviors.
Patients who have a history of limitation disorders, which are problems related to limitation from substances or behaviors.
Patients who have a history of restriction disorders, which are problems related to restriction from substances or behaviors.
Patients who have a history of constraint disorders, which are problems related to constraint from substances or behaviors.
Patients who have a history of inhibition disorders, which are problems related to inhibition from substances or behaviors.
Patients who have a history of suppression disorders, which are problems related to suppression from substances or behaviors.
Patients who have a history of repression disorders, which are problems related to repression from substances or behaviors.
Patients who have a history of oppression disorders, which are problems related to oppression from substances or behaviors.
Patients who have a history of depression disorders, which are problems related to depression from substances or behaviors.
Patients who have a history of suppression disorders, which are problems related to suppression from substances or behaviors.
Patients who have a history of repression disorders, which are problems related to repression from substances or behaviors.
Patients who have a history of oppression disorders, which are problems related to oppression from substances or behaviors.
Patients who have a history of depression disorders, which are problems related to depression from substances or behaviors.
Patients who have a history of suppression disorders, which are problems related to suppression from substances or behaviors.
Patients who have a history of repression disorders, which are problems related to repression from substances or behaviors.
Patients who have a history of oppression disorders, which are problems related to oppression from substances or behaviors.
Patients who have a history of depression disorders, which are problems related to depression from substances or behaviors.
Patients who have a history of suppression disorders, which are problems related to suppression from substances or behaviors.
Patients who have a history of repression disorders, which are problems related to repression from substances or behaviors.
Patients who have a history of oppression disorders, which are problems related to oppression from substances or behaviors.
Patients who have a history of depression disorders, which are problems related to depression from substances or behaviors.
Patients who have a history of suppression disorders, which are problems related to suppression from substances or behaviors.
Patients who have a history of repression disorders, which are problems related to repression from substances or behaviors.
Patients who have a history of oppression disorders, which are problems related to oppression from substances or behaviors.
Patients who have a history of depression disorders, which are problems related to depression from substances or behaviors.
Patients who have a history of suppression disorders, which are problems related to suppression from substances or behaviors.
Patients who have a history of repression disorders, which are problems related to repression from substances or behaviors.
Patients who have a history of oppression disorders, which are problems related to oppression from substances or behaviors.
Patients who have a history of depression disorders, which are problems related to depression from substances or behaviors.
Patients who have a history of suppression disorders, which are problems related to suppression from substances or behaviors.
Patients who have a history of repression disorders, which are problems related to repression from substances or behaviors.
Patients who have a history of oppression disorders, which are problems related to oppression from substances or behaviors.
Patients who have a history of depression disorders, which are problems related to depression from substances or behaviors.
Patients who have a history of suppression disorders, which are problems related to suppression from substances or behaviors.
Patients who have a history of repression disorders, which are problems related to repression from substances or behaviors.
Patients who have a history of oppression disorders, which are problems related to oppression from substances or behaviors.
Patients who have a history of depression disorders, which are problems related to depression from substances or behaviors.
Patients who have a history of suppression disorders, which are problems related to suppression from substances or behaviors.
Patients who have a history of repression disorders, which are problems related to repression from substances or behaviors.
Patients who have a history of oppression disorders, which are problems related to oppression from substances or behaviors.
Patients who have a history of depression disorders, which are problems related to depression from substances or behaviors.
Patients who have a history of suppression disorders, which are problems related to suppression from substances or behaviors.
Patients who have a history of repression disorders, which are problems related to repression from substances or behaviors.
Patients who have a history of oppression disorders, which are problems related to oppression from substances or behaviors.
Patients who have a history of depression disorders, which are problems related to depression from substances or behaviors.
Patients who have a history of suppression disorders, which are problems related to suppression from substances or behaviors.
Patients who have a history of repression disorders, which are problems related to repression from substances or behaviors.
Patients who have a history of oppression disorders, which are problems related to oppression from substances or behaviors.
Patients who have a history of depression disorders, which are problems related to depression from substances or behaviors.
Patients who have a history of suppression disorders, which are problems related to suppression from substances or behaviors.
Patients who have a history of repression disorders, which are problems related to repression from substances or behaviors.
Patients who have a history of oppression disorders, which are problems related to oppression from substances or behaviors.
Patients who have a history of depression disorders, which are problems related to depression from substances or behaviors.
Patients who have a history of suppression disorders, which are problems related to suppression from substances or behaviors.
Patients who have a history of repression disorders, which are problems related to repression from substances or behaviors.
Patients who have a history of oppression disorders, which are problems related to oppression from substances or behaviors.
Patients who have a history of depression disorders, which are problems related to depression from substances or behaviors.
Patients who have a history of suppression disorders, which are problems related to suppression from substances or behaviors.
Patients who have a history of repression disorders, which are problems related to repression from substances or behaviors.
Patients who have a history of oppression disorders, which are problems related to oppression from substances or behaviors.
Patients who have a history of depression disorders, which are problems related to depression from substances or behaviors.
Patients who have a history of suppression disorders, which are problems related to suppression from substances or behaviors.
Patients who have a history of repression disorders, which are problems related to repression from substances or behaviors.
Patients who have a history of oppression disorders, which are problems related to oppression from substances or behaviors.
Patients who have a history of depression disorders, which are problems related to depression from substances or behaviors.
Patients who have a history of suppression disorders, which are problems related to suppression from substances or behaviors.
Patients who have a history of repression disorders, which are problems related to repression from substances or behaviors.
Patients who have a history of oppression disorders, which are problems related to oppression from substances or behaviors.
Patients who have a history of depression disorders, which are problems related to depression from substances or behaviors.
Patients who have a history of suppression disorders, which are problems related to suppression from substances or behaviors.
Patients who have a history of repression disorders, which are problems related to repression from substances or behaviors.
Patients who have a history of oppression disorders, which are problems related to oppression from substances or behaviors.
Patients who have a history of depression disorders, which are problems related to depression from substances or behaviors.
Patients who have a history of suppression disorders, which are problems related to suppression from substances or behaviors.
Patients who have a history of repression disorders, which are problems related to repression from substances or behaviors.
Patients who have a history of oppression disorders, which are problems related to oppression from substances or behaviors.
Patients who have a history of depression disorders, which are problems related to depression from substances or behaviors.
Patients who have a history of suppression disorders, which are problems related to suppression from substances or behaviors.
Patients who have a history of repression disorders, which are problems related to repression from substances or behaviors.
Patients who have a history of oppression disorders, which are problems related to oppression from substances or behaviors.
Patients who have a history of depression disorders, which are problems related to depression from substances or behaviors.
Patients who have a history of suppression disorders, which are problems related to suppression from substances or behaviors.
Patients who have a history of repression disorders, which are problems related to repression from substances or behaviors.
Patients who have a history of oppression disorders, which are problems related to oppression from substances or behaviors.
Patients who have a history of depression disorders, which are problems related to depression from substances or behaviors.
Patients who have a history of suppression disorders, which are problems related to suppression from substances or behaviors.
Patients who have a history of repression disorders, which are problems related to repression from substances or behaviors.
Patients who have a history of oppression disorders, which are problems related to oppression from substances or behaviors.
Patients who have a history of depression disorders, which are problems related to depression from substances or behaviors.
Patients who have a history of suppression disorders, which are problems related to suppression from substances or behaviors.
Patients who have a history of repression disorders, which are problems related to repression from substances or behaviors.
Patients who have a history of oppression disorders, which are problems related to oppression from substances or behaviors.
Patients who have a history of depression disorders, which are problems related to depression from substances or behaviors.
Patients who have a history of suppression disorders, which are problems related to suppression from substances or behaviors.
Patients who have a history of repression disorders, which are problems related to repression from substances or behaviors.
Patients who have a history of oppression disorders, which are problems related to oppression from substances or behaviors.
Patients who have a history of depression disorders, which are problems related to depression from substances or behaviors.
Patients who have a history of suppression disorders, which are problems related to suppression from substances or behaviors.
Patients who have a history of repression disorders, which are problems related to repression from substances or behaviors.
Patients who have a history of oppression disorders, which are problems related to oppression from substances or behaviors.
Patients who have a history of depression disorders, which are problems related to depression from substances or behaviors.
Patients who have a history of suppression disorders, which are problems related to suppression from substances or behaviors.
Patients who have a history of repression disorders, which are problems related to repression from substances or behaviors.
Patients who have a history of oppression disorders, which are problems related to oppression from substances or behaviors.
Patients who have a history of depression disorders, which are problems related to depression from substances or behaviors.
Patients who have a history of suppression disorders, which are problems related to suppression from substances or behaviors.
Patients who have a history of repression disorders, which are problems related to repression from substances or behaviors.
Patients who have a history of oppression disorders, which are problems related to oppression from substances or behaviors.
Patients who have a history of depression disorders, which are problems related to depression from substances or behaviors.
Patients who have a history of suppression disorders, which are problems related to suppression from substances or behaviors.
Patients who have a history of repression disorders, which are problems related to repression from substances or behaviors.
Patients who have a history of oppression disorders, which are problems related to oppression from substances or behaviors.
Patients who have a history of depression disorders, which are problems related to depression from substances or behaviors.
Patients who have a history of suppression disorders, which are problems related to suppression from substances or behaviors.
Patients who have a history of repression disorders, which are problems related to repression from substances or behaviors.
Patients who have a history of oppression disorders, which are problems related to oppression from substances or behaviors.
Patients who have a history of depression disorders, which are problems related to depression from substances or behaviors.
Patients who have a history of suppression disorders, which are problems related to suppression from substances or behaviors.
Patients who have a history of repression disorders, which are problems related to repression from substances or behaviors.
Patients who have a history of oppression disorders, which are problems related to oppression from substances or behaviors.
Patients who have a history of depression disorders, which are problems related to depression from substances or behaviors.
Patients who have a history of suppression disorders, which are problems related to suppression from substances or behaviors.
Patients who have a history of repression disorders, which are problems related to repression from substances or behaviors.
Patients who have a history of oppression disorders, which are problems related to oppression from substances or behaviors.
Patients who have a history of depression disorders, which are problems related to depression from substances or behaviors.
Patients who have a history of suppression disorders, which are problems related to suppression from substances or behaviors.
Patients who have a history of repression disorders, which are problems related to repression from substances or behaviors.
Patients who have a history of oppression disorders, which are problems related to oppression from substances or behaviors.
Patients who have a history of depression disorders, which are problems related to depression from substances or behaviors.
Patients who have a history of suppression disorders, which are problems related to suppression from substances or behaviors.
Patients who have a history of repression disorders, which are problems related to repression from substances or behaviors.
Patients who have a history of oppression disorders, which are problems related to oppression from substances or behaviors.
Patients who have a history of depression disorders, which are problems related to depression from substances or behaviors.
Patients who have a history of suppression disorders, which are problems related to suppression from substances or behaviors.
Patients who have a history of repression disorders, which are problems related to repression from substances or behaviors.
Patients who have a history of oppression disorders, which are problems related to oppression from substances or behaviors.
Patients who have a history of depression disorders, which are problems related to depression from substances or behaviors.
Patients who have a history of suppression disorders, which are problems related to suppression from substances or behaviors.
Patients who have a history of repression disorders, which are problems related to repression from substances or behaviors.
Patients who have a history of oppression disorders, which are problems related to oppression from substances or behaviors.
Patients who have a history of depression disorders, which are problems related to depression from substances or behaviors.
Patients who have a history of suppression disorders, which are problems related to suppression from substances or behaviors.
Patients who have a history of repression disorders, which are problems related to repression from substances or behaviors.
Patients who have a history of oppression disorders, which are problems related to oppression from substances or behaviors.
Patients who have a history of depression disorders, which are problems related to depression from substances or behaviors.
Patients who have a history of suppression disorders, which are problems related to suppression from substances or behaviors.
Patients who have a history of repression disorders, which are problems related to repression from substances or behaviors.
Patients who have a history of oppression disorders, which are problems related to oppression from substances or behaviors.
Patients who have a history of depression disorders, which are problems related to depression from substances or behaviors.
Patients who have a history of suppression disorders, which are problems related to suppression from substances or behaviors.
Patients who have a history of repression disorders, which are problems related to repression from substances or behaviors.
Patients who have a history of oppression disorders, which are problems related to oppression from substances or behaviors.
Patients who have a history of depression disorders, which are problems related to depression from substances or behaviors.
Patients who have a history of suppression disorders, which are problems related to suppression from substances or behaviors.
Patients who have a history of repression disorders, which are problems related to repression from substances or behaviors.
Patients who have a history of oppression disorders, which are problems related to oppression from substances or behaviors.
Patients who have a history of depression disorders, which are problems related to depression from substances or behaviors.
Patients who have a history of suppression disorders, which are problems related to suppression from substances or behaviors.
Patients who have a history of repression disorders, which are problems related to repression from substances or behaviors.
Patients who have a history of oppression disorders, which are problems related to oppression from substances or behaviors.
Patients who have a history of depression disorders, which are problems related to depression from substances or behaviors.
Patients who have a history of suppression disorders, which are problems related to suppression from substances or behaviors.
Patients who have a history of repression disorders, which are problems related to repression from substances or behaviors.
Patients who have a history of oppression disorders, which are problems related to oppression from substances or behaviors.
Patients who have a history of depression disorders, which are problems related to depression from substances or behaviors.
Patients who have a history of suppression disorders, which are problems related to suppression from substances or behaviors.
Patients who have a history of repression disorders, which are problems related to repression from substances or behaviors.
Patients who have a history of oppression disorders, which are problems related to oppression from substances or behaviors.
Patients who have a history of depression disorders, which are problems related to depression from substances or behaviors.
Patients who have a history of suppression disorders, which are problems related to suppression from substances or behaviors.
Patients who have a history of repression disorders, which are problems related to repression from substances or behaviors.
Patients who have a history of oppression disorders, which are problems related to oppression from substances or behaviors.
Patients who have a history of depression disorders, which are problems related to depression from substances or behaviors.
Patients who have a history of suppression disorders, which are problems related to suppression from substances or behaviors.
Patients who have a history of repression disorders, which are problems related to repression from substances or behaviors.
Patients who have a history of oppression disorders, which are problems related to oppression from substances or behaviors.
Patients who have a history of depression disorders, which are problems related to depression from substances or behaviors.
Patients who have a history of suppression disorders, which are problems related to suppression from substances or behaviors.
Patients who have a history of repression disorders, which are problems related to repression from substances or behaviors.
Patients who have a history of oppression disorders, which are problems related to oppression from substances or behaviors.
Patients who have a history of depression disorders, which are problems related to depression from substances or behaviors.
Patients who have a history of suppression disorders, which are problems related to suppression from substances or behaviors.
Patients who have a history of repression disorders, which are problems related to repression from substances or behaviors.
Patients who have a history of oppression disorders, which are problems related to oppression from substances or behaviors.
Patients who have a history of depression disorders, which are problems related to depression from substances or behaviors.
Patients who have a history of suppression disorders, which are problems related to suppression from substances or behaviors.
Patients who have a history of repression disorders, which are problems related to repression from substances or behaviors.
Patients who have a history of oppression disorders, which are problems related to oppression from substances or behaviors.
Patients who have a history of depression disorders, which are problems related to depression from substances or behaviors.
Patients who have a history of suppression disorders, which are problems related to suppression from substances or behaviors.
Patients who have a history of repression disorders, which are problems related to repression from substances or behaviors.
Patients who have a history of oppression disorders, which are problems related to oppression from substances or behaviors.
Patients who have a history of depression disorders, which are problems related to depression from substances or behaviors.
Patients who have a history of suppression disorders, which are problems related to suppression from substances or behaviors.
Patients who have a history of repression disorders, which are problems related to repression from substances or behaviors.
Patients who have a history of oppression disorders, which are problems related to oppression from substances or behaviors.
Patients who have a history of depression disorders, which are problems related to depression from substances or behaviors.
Patients who have a history of suppression disorders, which are problems related to suppression from substances or behaviors.
Patients who have a history of repression disorders, which are problems related to repression from substances or behaviors.
Patients who have a history of oppression disorders, which are problems related to oppression from substances or behaviors.
Patients who have a history of depression disorders, which are problems related to depression from substances or behaviors.
Patients who have a history of suppression disorders, which are problems related to suppression from substances or behaviors.
Patients who have a history of repression disorders, which are problems related to repression from substances or behaviors.
Patients who have a history of oppression disorders, which are problems related to oppression from substances or behaviors.
Patients who have a history of depression disorders, which are problems related to depression from substances or behaviors.
Patients who have a history of suppression disorders, which are problems related to suppression from substances or behaviors.
Patients who have a history of repression disorders, which are problems related to repression from substances or behaviors.
Patients who have a history of oppression disorders, which are problems related to oppression from substances or behaviors.
Patients who have a history of depression disorders, which are problems related to depression from substances or behaviors.
Patients who have a history of suppression disorders, which are problems related to suppression from substances or behaviors.
Patients who have a history of repression disorders, which are problems related to repression from substances or behaviors.
Patients who have a history of oppression disorders, which are problems related to oppression from substances or behaviors.
Patients who have a history of depression disorders, which are problems related to depression from substances or behaviors.
Patients who have a history of suppression disorders, which are problems related to suppression from substances or behaviors.
Patients who have a history of repression disorders, which are problems related to repression from substances or behaviors.
Patients who have a history of oppression disorders, which are problems related to oppression from substances or behaviors.
Patients who have a history of depression disorders, which are problems related to depression from substances or behaviors.
Patients who have a history of suppression disorders, which are problems related to suppression from substances or behaviors.
Patients who have a history of repression disorders, which are problems related to repression from substances or behaviors.
Patients who have a history of oppression disorders, which are problems related to oppression from substances or behaviors.
Patients who have a history of depression disorders, which are problems related to depression from substances or behaviors.
Patients who have a history of suppression disorders, which are problems related to suppression from substances or behaviors.
Patients who have a history of repression disorders, which are problems related to repression from substances or behaviors.
Patients who have a history of oppression disorders, which are problems related to oppression from substances or behaviors.
Patients who have a history of depression disorders, which are problems related to depression from substances or behaviors.
Patients who have a history of suppression disorders, which are problems related to suppression from substances or behaviors.
Patients who have a history of repression disorders, which are problems related to repression from substances or behaviors.
Patients who have a history of oppression disorders, which are problems related to oppression from substances or behaviors.
Patients who have a history of depression disorders, which are problems related to depression from substances or behaviors.
Patients who have a history of suppression disorders, which are problems related to suppression from substances or behaviors.
Patients who have a history of repression disorders, which are problems related to repression from substances or behaviors.
Patients who have a history of oppression disorders, which are problems related to oppression from substances or behaviors.
Patients who have a history of depression disorders, which are problems related to depression from substances or behaviors.
Patients who have a history of suppression disorders, which are problems related to suppression from substances or behaviors.
Patients who have a history of repression disorders, which are problems related to repression from substances or behaviors.
Patients who have a history of oppression disorders, which are problems related to oppression from substances or behaviors.
Patients who have a history of depression disorders, which are problems related to depression from substances or behaviors.
Patients who have a history of suppression disorders, which are problems related to suppression from substances or behaviors.
Patients who have a history of repression disorders, which are problems related to repression from substances or behaviors.
Patients who have a history of oppression disorders, which are problems related to oppression from substances or behaviors.
Patients who have a history of depression disorders, which are problems related to depression from substances or behaviors.
Patients who have a history of suppression disorders, which are problems related to suppression from substances or behaviors.
Patients who have a history of repression disorders, which are problems related to repression from substances or behaviors.
Patients who have a history of oppression disorders, which are problems related to oppression from substances or behaviors.
Patients who have a history of depression disorders, which are problems related to depression from substances or behaviors.
Patients who have a history of suppression disorders, which are problems related to suppression from substances or behaviors.
Patients who have a history of repression disorders, which are problems related to repression from substances or behaviors.
Patients who have a history of oppression disorders, which are problems related to oppression from substances or behaviors.
Patients who have a history of depression disorders, which are problems related to depression from substances or behaviors.
Patients who have a history of suppression disorders, which are problems related to suppression from substances or behaviors.
Patients who have a history of repression disorders, which are problems related to repression from substances or behaviors.
Patients who have a history of oppression disorders, which are problems related to oppression from substances or behaviors.
Patients who have a history of depression disorders, which are problems related to depression from substances or behaviors.
Patients who have a history of suppression disorders, which are problems related to suppression from substances or behaviors.
Patients who have a history of repression disorders, which are problems related to repression from substances or behaviors.
Patients who have a history of oppression disorders, which are problems related to oppression from substances or behaviors.
Patients who have a history of depression disorders, which are problems related to depression from substances or behaviors.
Patients who have a history of suppression disorders, which are problems related to suppression from substances or behaviors.
Patients who have a history of repression disorders, which are problems related to repression from substances or behaviors.
Patients who have a history of oppression disorders, which are problems related to oppression from substances or behaviors.
Patients who have a history of depression disorders, which are problems related to depression from substances or behaviors.
Patients who have a history of suppression disorders, which are problems related to suppression from substances or behaviors.
Patients who have a history of repression disorders, which are problems related to repression from substances or behaviors.
Patients who have a history of oppression disorders, which are problems related to oppression from substances or behaviors.
Patients who have a history of depression disorders, which are problems related to depression from substances or behaviors.
Patients who have a history of suppression disorders, which are problems related to suppression from substances or behaviors.
Patients who have a history of repression disorders, which are problems related to repression from substances or behaviors.
Patients who have a history of oppression disorders, which are problems related to oppression from substances or behaviors.
Patients who have a history of depression disorders, which are problems related to depression from substances or behaviors.
Patients who have a history of suppression disorders, which are problems related to suppression from substances or behaviors.
Patients who have a history of repression disorders, which are problems related to repression from substances or behaviors.
Patients who have a history of oppression disorders, which are problems related to oppression from substances or behaviors.
Patients who have a history of depression disorders, which are problems related to depression from substances or behaviors.
Patients who have a history of suppression disorders, which are problems related to suppression from substances or behaviors.
Patients who have a history of repression disorders, which are problems related to repression from substances or behaviors.
Patients who have a history of oppression disorders, which are problems related to oppression from substances or behaviors.
Patients who have a history of depression disorders, which are problems related to depression from substances or behaviors.
Patients who have a history of suppression disorders, which are problems related to suppression from substances or behaviors.
Patients who have a history of repression disorders, which are problems related to repression from substances or behaviors.
Patients who have a history of oppression disorders, which are problems related to oppression from substances or behaviors.
Patients who have a history of depression disorders, which are problems related to depression from substances or behaviors.
Patients who have a history of suppression disorders, which are problems related to suppression from substances or behaviors.
Patients who have a history of repression disorders, which are problems related to repression from substances or behaviors.
Patients who have a history of oppression disorders, which are problems related to oppression from substances or behaviors.
Patients who have a history of depression disorders, which are problems related to depression from substances or behaviors.
Patients who have a history of suppression disorders, which are problems related to suppression from substances or behaviors.
Patients who have a history of repression disorders, which are problems related to repression from substances or behaviors.
Patients who have a history of oppression disorders, which are problems related to oppression from substances or behaviors.
Patients who have a history of depression disorders, which are problems related to depression from substances or behaviors.
Patients who have a history of suppression disorders, which are problems related to suppression from substances or behaviors.
Patients who have a history of repression disorders, which are problems related to repression from substances or behaviors.
Patients who have a history of oppression disorders, which are problems related to oppression from substances or behaviors.
Patients who have a history of depression disorders, which are problems related to depression from substances or behaviors.
Patients who have a history of suppression disorders, which are problems related to suppression from substances or behaviors.
Patients who have a history of repression disorders, which are problems related to repression from substances or behaviors.
Patients who have a history of oppression disorders, which are problems related to oppression from substances or behaviors.
Patients who have a history of depression disorders, which are problems related to depression from substances or behaviors.
Patients who have a history of suppression disorders, which are problems related to suppression from substances or behaviors.
Patients who have a history of repression disorders, which are problems related to repression from substances or behaviors.
Patients who have a history of oppression disorders, which are problems related to oppression from substances or behaviors.
Patients who have a history of depression disorders, which are problems related to depression from substances or behaviors.
Patients who have a history of suppression disorders, which are problems related to suppression from substances or behaviors.
Patients who have a history of repression disorders, which are problems related to repression from substances or behaviors.
Patients who have a history of oppression disorders, which are problems related to oppression from substances or behaviors.
Patients who have a history of depression disorders, which are problems related to depression from substances or behaviors.
Patients who have a history of suppression disorders, which are problems related to suppression from substances or behaviors.
Patients who have a history of repression disorders, which are problems related to repression from substances or behaviors.
Patients who have a history of oppression disorders, which are problems related to oppression from substances or behaviors.
Patients who have a history of depression disorders, which are problems related to depression from substances or behaviors.
Patients who have a history of suppression disorders, which are problems related to suppression from substances or behaviors.
Patients who have a history of repression disorders, which are problems related to repression from substances or behaviors.
Patients who have a history of oppression disorders, which are problems related to oppression from substances or behaviors.
Patients who have a history of depression disorders, which are problems related to depression from substances or behaviors.
Patients who have a history of suppression disorders, which are problems related to suppression from substances or behaviors.
Patients who have a history of repression disorders, which are problems related to repression from substances or behaviors.
Patients who have a history of oppression disorders, which are problems related to oppression from substances or behaviors.
Patients who have a history of depression disorders, which are problems related to depression from substances or behaviors.
Patients who have a history of suppression disorders, which are problems related to suppression from substances or behaviors.
Patients who have a history of repression disorders, which are problems related to repression from substances or behaviors.
Patients who have a history of oppression disorders, which are problems related to oppression from substances or behaviors.
Patients who have a history of depression disorders, which are problems related to depression from substances or behaviors.
Patients who have a history of suppression disorders, which are problems related to suppression from substances or behaviors.
Patients who have a history of repression disorders, which are problems related to repression from substances or behaviors.
Patients who have a history of oppression disorders, which are problems related to oppression from substances or behaviors.
Patients who have a history of depression disorders, which are problems related to depression from substances or behaviors.
Patients who have a history of suppression disorders, which are problems related to suppression from substances or behaviors.
Patients who have a history of repression disorders, which are problems related to repression from substances or behaviors.
Patients who have a history of oppression disorders, which are problems related to oppression from substances or behaviors.
Patients who have a history of depression disorders, which are problems related to depression from substances or behaviors.
Patients who have a history of suppression disorders, which are problems related to suppression from substances or behaviors.
Patients who have a history of repression disorders, which are problems related to repression from substances or behaviors.
Patients who have a history of oppression disorders, which are problems related to oppression from substances or behaviors.
Patients who have a history of depression disorders, which are problems related to depression from substances or behaviors.
Patients who have a history of suppression disorders, which are problems related to

Where you can join this trial?

Verified and Recommended Sites

No sites found in this category

Verified Sites

Site Name	City	Country
Technische Universitaet Dresden	Dresden	Germany
Spitalul Clinic Judetean De Urgenta Cluj	Cluj Napoca	Romania
Krankenhaus Porz Am Rhein gGmbH	Cologne	Germany
Respublikine Klaipedos ligonine VšĮ	Klaipeda	Lithuania
Poliklinika Vlatka Cavka d.o.o.	Zagreb	Croatia
Medicover Integrated Clinical Services Sp. z o.o.	Bydgoszcz	Poland
Center For Pediatric And Adolescent Medicine Of The Johannes Gutenberg University Mainz	Mainz	Germany
Université Libre de Bruxelles – Hôpital Erasme	Brussels	Belgium
Innomedica OÜ	Tallin	Estonia
Zazabie s.r.o.	Kosice	Slovakia

Other Sites

Site Name	City	Country
Azienda Ospedaliera di Padova	Padua	Italy
Szpital Uniwersytecki Nr 2 Im Dr Jana Biziela W Bydgoszczy	Bydgoszcz	Poland
UNIMED Medical Center EOOD	Plovdiv	Bulgaria
Vilniaus universiteto ligonine Santaros klinikos VšĮ	Vilnius	Lithuania
Hospital Universitario Virgen De Valme	Sevilla	Spain
Medical Center Artmed Ltd.	Plovdiv	Bulgaria
Poliklinika Solmed d.o.o.	Zagreb	Croatia
Vita Verum Medical Bt.	Szekesfehervar	Hungary
University Of Pecs	Pecs	Hungary
Narodny Ustav Reumatickych Chorob	Piestany	Slovakia
Thermium s.r.o.	Piestany	Slovakia
East Tallinn Central Hospital	Tallin	Estonia
MediTrials OÜ	Tartu	Estonia
Pauls Stradins Clinical University Hospital	Riga	Latvia
Hopitaux Universitaires Pitie Salpetriere	Paris	France
University Of Debrecen	Debrecen	Hungary
Medical Center Excelsior OOD	Sofia	Bulgaria
Dkc Fokus-5 Lzip OOD	Sofia	Bulgaria
Opca Bolnica Zadar	Zadar	Croatia
Clinical Medical Center Osijek	Osijek	Croatia
Centre Hospitalier Universitaire De Toulouse	Toulouse	France
Universita’ Di Pisa	Pisa	Italy
Universita’ Politecnica Delle Marche	Ancona	Italy
Liepajas Regionala Slimnica SIA	Liepaja	Latvia
Klaipedos universiteto ligonine VšĮ	Klaipeda	Lithuania
KBC Split	Split	Croatia
Saint Maria Hospital	Bucharest	Romania
Vrije Universiteit Brussel	Jette	Belgium
San Camillo Forlanini Hospital	Rome	Italy
Lietuvos sveikatos mokslu universiteto ligonine Kauno klinikos	Kaunas	Lithuania
Bekes Varmegyei Koezponti Korhaz	Gyula	Hungary
University General Hospital Of Heraklion	Heraklion	Greece
Etyka Osrodek Badan Klinicznych Tomasz Pesta S.K.A.	Olsztyn	Poland
Medman s.r.o.	Martin	Slovakia
Artromac N.O.	Kosice	Slovakia
Daugavpils regionala slimnica SIA	Daugavpils	Latvia
University Multiprofile Hospital For Active Treatment Kaspela EOOD	Plovdiv	Bulgaria
Medical Center Teodora EOOD	Ruse	Bulgaria
Unidade Local De Saude Do Alto Minho E.P.E.	Ponte De Lima	Portugal
ZNA Jan Palfijn	Antwerp	Belgium
North Estonia Medical Centre Foundation	Tallin	Estonia
Ortopedyczno-Rehabilitacyjny Szpital Kliniczny Im Wiktora Degi Uniwersytetu Medycznego Im Karola Marcinkowskiego W Poznaniu	Poznan	Poland
Vital-Medicina Kft.	Veszprem	Hungary
Medical Center Academy LTD	Sofia	Bulgaria
Hospital La Croix Rousse Hcl	Lyon	France
Mqrarrgcq Irxlcnqgzx Cgipudbq Srcjtkqv Spz z okgm	Warsaw	Poland
Rvkgc Anxrshfe kllfikwb uroahgyzjryda sebqnhjd Svn	Riga	Latvia
Cpvmxv Hdrtlkdvqn Uxskrgiysjwri Dg Paiud Egksdn	Porto	Portugal
Itddpewntvrkphmaihdb Gsre	Berlin	Germany
Lxqdd Gyqnloe Hwlnsvmi Ov Abeezx	Athens	Greece
Kwahcyrk baitztol czehnv Rofoak (scwckcgm Hikkbpso Ccjbft Rufgrun	Rijeka	Croatia
Uwsouvkdsa Dmqmj Sgjpo Du Rzdc Lm Sisgdthf	Rome	Italy
Hmmfsbun Uumsgevdjgbza Mskirnb Dm Vgucretjsj	Santander	Spain
Cdcxhcc Mcuidxt Dp Dsjuwevqwy Su Txpkvdmta Azlvcsjns Nqnyft Sobbhl	Brasov	Romania
Cwpyohep Hijfeuhzdcyo Udigbjlqvywge Dw Vkrc	Vigo	Spain
Cesvmd Hyhmbrjtri Dy Taqvmj E Sehbt Expseq	Guilhufe	Portugal
Irfsztbu Uuj	Kaunas	Lithuania
Hfztswvh Uowcfysojmvbv dd A Czpikp	A Coruna Galicia	Spain
Uvombnpjju Gfnfeep Hidhhqxi Aakgkwt	Athens	Greece
M &mwbk M ctokpv Shz	Adazi	Latvia
Mjkmqkpi moiwezg aeugife &jhkqwk Mmwh &zocntw Sybmb	Sofia	Bulgaria
D Schtwxmi Kbeyfrecwi Pkrdkzh Piuljnqm	Liepaja	Latvia

Trial status

Country	Status	Recruitment Start
Belgium	Not recruiting	01.10.2023
Bulgaria	Not recruiting	01.10.2023
Croatia	Not recruiting	01.10.2023
Estonia	Not recruiting	01.10.2023
France	Not recruiting	01.10.2023
Germany	Not recruiting	01.10.2023
Greece	Not recruiting	01.10.2023
Hungary	Not recruiting	01.10.2023
Italy	Not recruiting	01.10.2023
Latvia	Not recruiting	01.10.2023
Lithuania	Not recruiting	01.10.2023
Poland	Not recruiting	01.10.2023
Portugal	Not recruiting	01.10.2023
Romania	Not recruiting	01.10.2023
Slovakia	Not recruiting	01.10.2023
Spain	Not recruiting	01.10.2023

Trial locations

Investigated drugs:

Upadacitinib

Upadacitinib is a medication being studied for its ability to treat signs and symptoms of moderately to severely active Systemic Lupus Erythematosus (SLE). The trial aims to assess both the safety and effectiveness of this medication over a period of 52 weeks. Upadacitinib is being compared to a placebo to determine if it provides superior results in managing SLE symptoms. Additionally, the study includes a long-term extension to further evaluate the safety of upadacitinib in patients with SLE.

Systemic Lupus Erythematosus – Systemic Lupus Erythematosus (SLE) is an autoimmune disease where the immune system mistakenly attacks healthy tissues in the body. It can affect various parts of the body, including the skin, joints, kidneys, brain, and other organs. The disease often presents with symptoms such as fatigue, joint pain, skin rashes, and fever. SLE is characterized by periods of illness, called flares, and periods of remission when symptoms improve. The severity and progression of the disease can vary widely among individuals. Over time, SLE can lead to complications in the affected organs if not managed properly.

Trial ID:

2023-503655-10-00

Protocol code:

M23-699

NCT ID:

NCT05843643

Trial Phase:

Therapeutic confirmatory (Phase III)

Other Trials to Consider

#1 Clinical Trials Search in Europe

Study on the Effects of Upadacitinib in Adults with Moderate to Severe Systemic Lupus Erythematosus (SLE)

What is this study about?

Who Can Join the Study?

Who Cannot Join the Study?