Insulin is a hormone that helps control blood sugar levels in the body. In this trial, it is used to understand how weight loss affects the body’s ability to manage sugar and fat, especially in people with obesity and fatty liver disease. Insulin helps the body use sugar from carbohydrates in the food you eat for energy or to store glucose for future use. It also helps keep your blood sugar level from getting too high or too low.

Obesity – Obesity is a condition characterized by excessive body fat accumulation that may impair health. It develops when there is an imbalance between calorie intake and energy expenditure, leading to weight gain. Over time, this excess weight can affect various bodily systems, including the cardiovascular and metabolic systems. As obesity progresses, it can lead to increased fat storage in tissues and organs, contributing to further health complications. The condition is often associated with other metabolic disorders, such as insulin resistance. Obesity can also impact physical mobility and overall quality of life.

Non-alcoholic Fatty Liver Disease – Non-alcoholic Fatty Liver Disease (NAFLD) is a condition where excess fat builds up in the liver in individuals who consume little to no alcohol. It typically begins with simple steatosis, where fat accumulates in liver cells without causing significant damage. As the disease progresses, it can lead to inflammation and liver cell injury, a condition known as non-alcoholic steatohepatitis (NASH). Over time, persistent inflammation may result in fibrosis, where scar tissue forms in the liver. If fibrosis continues to develop, it can lead to cirrhosis, a severe form of liver damage. NAFLD is often associated with metabolic conditions such as obesity and insulin resistance.