This study focuses on pregnant women with premature rupture of membranes (PROM), a condition where the water breaks before labor begins. The study aims to determine if early induction of labor can reduce the need for breathing support in newborns compared to waiting for labor to start naturally.
The study will use several medications to help start labor: oxytocin, a hormone given through a vein that helps the uterus contract; dinoprostone, a medication used vaginally to prepare the cervix and induce labor; and misoprostol, a medication taken by mouth that also helps induce labor. Mifepristone may also be used to help prepare the body for labor.
During the study, women will be randomly assigned to either receive these medications to start labor right away or wait for labor to begin on its own. The study will track how many newborns need breathing support after birth, as well as monitor for other health outcomes in both mothers and babies. This includes checking for signs of infection, monitoring the pattern of uterine contractions, and keeping track of how long mothers and babies need to stay in the hospital.



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