This study focuses on patients with severe influenza (flu) infection who require intensive care and breathing support through a ventilator. The main treatments being studied are oseltamivir (sold under the brand name Tamiflu) and paracetamol. Oseltamivir is a medication used to treat flu infections, while paracetamol is a common pain and fever reducer.
The purpose of this research is to understand how the amount of oseltamivir medicine in the blood affects recovery in severely ill flu patients. The study will look at patients who are receiving oseltamivir through a feeding tube while on breathing support. Researchers will measure the levels of the medicine in patients’ blood after 48 hours of treatment.
During the study, patients will receive regular doses of oseltamivir for up to 10 days. Blood samples will be taken to measure medicine levels, and throat swabs will be collected to check for flu virus. The study will track how long patients need breathing support and monitor their recovery over 90 days. This information will help doctors understand if adjusting medicine doses could lead to better treatment outcomes for severely ill flu patients.



France