Durvalumab is a medication used in this trial to help the immune system attack cancer cells. It is a type of immunotherapy that works by blocking a protein that stops the immune system from working properly, allowing it to better fight the cancer.

Bevacizumab is a medication that helps to prevent the growth of new blood vessels that tumors need to grow. By blocking these blood vessels, it can help to slow down or stop the growth of the cancer.

Olaparib is a medication that targets cancer cells with specific genetic defects. It works by interfering with the cancer cells’ ability to repair their DNA, which can lead to the death of these cells. This medication is used as part of the maintenance therapy in the trial to help keep the cancer from coming back after initial treatment.

High Grade Epithelial Ovarian Cancer – This is a type of cancer that begins in the cells on the surface of the ovary. It is characterized by its rapid growth and tendency to spread to other parts of the body, often being diagnosed at an advanced stage. The disease progresses as cancer cells multiply and invade nearby tissues, potentially spreading to the abdominal lining and other organs. Symptoms may include abdominal bloating, pelvic pain, and changes in bowel habits. The progression of the disease can lead to the accumulation of fluid in the abdomen and other complications. Early detection is challenging due to the subtlety of initial symptoms.

Fallopian Tube Cancer – This rare cancer originates in the fallopian tubes, which connect the ovaries to the uterus. It often presents with symptoms similar to ovarian cancer, such as pelvic pain and abnormal vaginal discharge. The disease progresses as cancer cells grow and may spread to nearby organs and tissues. It is typically diagnosed at an advanced stage due to the lack of specific early symptoms. The cancer can cause blockages in the fallopian tubes, leading to further complications. As it advances, it may spread to the abdominal cavity and beyond.

Primary Peritoneal Cancer – This cancer develops in the peritoneum, the lining of the abdominal cavity, and is closely related to ovarian cancer. It progresses similarly to ovarian cancer, with cancer cells spreading across the peritoneal surface. Symptoms can include abdominal pain, bloating, and digestive disturbances. The disease often advances before being detected, as early symptoms are non-specific. It can lead to the accumulation of fluid in the abdomen, known as ascites. The cancer may spread to other abdominal organs and tissues as it progresses.